PMID- 19162345
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20220316
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 142
IP  - 2
DP  - 2010 Jul 9
TI  - Impact of depression on quality of life assessment in heart failure.
PG  - 133-7
LID - 10.1016/j.ijcard.2008.12.093 [doi]
AB  - BACKGROUND: Depression is highly prevalent in patients with chronic heart failure 
      (CHF) and may bias patients' reports of their health-related quality of life 
      (HRQoL). Depressed patients may rate their limitations of HRQoL worse even when 
      their condition is rather good. We aimed to examine whether co-morbid depression 
      alters the relationship between disease severity and HRQoL, thus compromising the 
      validity of a CHF-specific HRQoL measure. METHODS: A sample of 233 outpatients 
      with CHF (mean age 64.5 years, 70% male) was evaluated. Depression was measured 
      with the Patient Health Questionnaire and CHF-specific HRQoL with the Kansas City 
      Cardiomyopathy Questionnaire (KCCQ). CHF severity was assessed with physician 
      ratings of the New York Heart Association (NYHA) functional class. RESULTS: Both 
      NYHA functional class and depression independently impacted the various subscales 
      of the KCCQ. Regarding the symptom- and function-related subscales, a 
      dose-response relationship between disease severity and HRQoL was observed also 
      in depressed patients. In contrast, in the quality of life subscale covering life 
      satisfaction an interaction effect of disease severity and depression was found. 
      In this subscale, a dose-response relationship between increasing disease 
      severity and worsening HRQoL was no longer present among the depressed. 
      CONCLUSIONS: Both disease severity and depression impacted each heart 
      failure-specific HRQoL dimension while the presence of depression seemed to 
      distort the relationship between disease severity and HRQoL in the quality of 
      life subscale. As quality of life may depend more on the presence of depression 
      than on the severity of CHF, assessing depression may help interpreting HRQoL 
      scores.
CI  - Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
FAU - Faller, Hermann
AU  - Faller H
AD  - Department of Internal Medicine I/Center for Cardiovascular Medicine, University 
      of Wurzburg, Institute of Psychotherapy und Medical Psychology, Wurzburg, 
      Germany. h.faller@uni-wuerzburg.de
FAU - Steinbuchel, Thomas
AU  - Steinbuchel T
FAU - Stork, Stefan
AU  - Stork S
FAU - Schowalter, Marion
AU  - Schowalter M
FAU - Ertl, Georg
AU  - Ertl G
FAU - Angermann, Christiane E
AU  - Angermann CE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090121
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Depressive Disorder/*complications/diagnosis/*psychology
MH  - Female
MH  - Heart Failure/*complications/diagnosis/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Severity of Illness Index
MH  - *Sickness Impact Profile
EDAT- 2009/01/24 09:00
MHDA- 2011/02/23 06:00
CRDT- 2009/01/24 09:00
PHST- 2008/09/12 00:00 [received]
PHST- 2008/12/13 00:00 [accepted]
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - S0167-5273(08)01497-6 [pii]
AID - 10.1016/j.ijcard.2008.12.093 [doi]
PST - ppublish
SO  - Int J Cardiol. 2010 Jul 9;142(2):133-7. doi: 10.1016/j.ijcard.2008.12.093. Epub 
      2009 Jan 21.