PMID- 19162578
OWN - NLM
STAT- MEDLINE
DCOM- 20090507
LR  - 20200928
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2008
DP  - 2008
TI  - Intravascular ultrasound and photoacoustic imaging.
PG  - 2-5
LID - 10.1109/IEMBS.2008.4649075 [doi]
AB  - There is a need for an imaging technique that can reliably identify and 
      characterize the vulnerability of atherosclerotic plaques. Catheter-based 
      intravascular ultrasound (IVUS) is one of the imaging tools of the clinical 
      evaluation of atherosclerosis. However, histopathological information obtained 
      with IVUS imaging is limited. We present and discuss the applicability of a 
      combined intravascular photoacoustic (IVPA) and intravascular ultrasound (IVUS) 
      imaging approach to assess both vessel structure and tissue composition thus 
      identifying rupture-prone atherosclerotic plaques. Photoacoustic (or optoacoustic 
      and, generally, thermoacoustic) imaging relies on the absorption of 
      electromagnetic energy, such as light, and the subsequent emission of an acoustic 
      wave. Therefore, the amplitude and temporal characteristics of the photoacoustic 
      signal is primarily determined by optical absorption properties of different 
      types of tissues and can be used to differentiate the lipid, fibrous and 
      fibro-cellular components of an inflammatory lesion. Simultaneous IVUS and IVPA 
      imaging studies were conducted using 40 MHz clinical IVUS imaging catheter 
      interfaced with a pulsed laser system. The performance of the IVPA/IVUS imaging 
      was assessed using phantoms with point targets and vessel-mimicking phantoms. To 
      detect the lipids in the plaque, ex-vivo IVPA imaging studies of a normal and an 
      atherosclerotic rabbit aorta were performed at a 532 nm wavelength. To assess 
      plaque composition, multi-wavelength (680-950 nm) spectroscopic IVPA imaging 
      studies were carried out. Finally, molecular and cellular IVPA imaging was 
      demonstrated using plasmonic nanoparticles. Overall, our studies suggest that 
      plaque detection and characterization can be improved using the combined 
      IVPA/IVUS imaging.
FAU - Emelianov, Stanislav
AU  - Emelianov S
AD  - Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 
      78712, USA. emelian@mail.utexas.edu
FAU - Wang, Bo
AU  - Wang B
FAU - Su, Jimmy
AU  - Su J
FAU - Karpiouk, Andrei
AU  - Karpiouk A
FAU - Yantsen, Evgeniya
AU  - Yantsen E
FAU - Sokolov, Konstantin
AU  - Sokolov K
FAU - Amirian, James
AU  - Amirian J
FAU - Smalling, Richard
AU  - Smalling R
FAU - Sethuraman, Shriram
AU  - Sethuraman S
LA  - eng
GR  - EB004963/EB/NIBIB NIH HHS/United States
GR  - EB008101/EB/NIBIB NIH HHS/United States
GR  - HL084076/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Animals
MH  - Catheterization/*methods
MH  - Coronary Artery Disease/*diagnostic imaging
MH  - Echocardiography/*methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Phantoms, Imaging
MH  - Rabbits
EDAT- 2009/01/24 09:00
MHDA- 2009/05/08 09:00
CRDT- 2009/01/24 09:00
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2009/05/08 09:00 [medline]
AID - 10.1109/IEMBS.2008.4649075 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2008;2008:2-5. doi: 
      10.1109/IEMBS.2008.4649075.