PMID- 19165148
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20220408
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 28
IP  - 5
DP  - 2009 Mar 4
TI  - Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress 
      acclimation in Arabidopsis.
PG  - 591-601
LID - 10.1038/emboj.2009.4 [doi]
AB  - The ultraviolet-B (UV-B) portion of the solar radiation functions as an 
      environmental signal for which plants have evolved specific and sensitive UV-B 
      perception systems. The UV-B-specific UV RESPONSE LOCUS 8 (UVR8) and the 
      multifunctional E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) are 
      key regulators of the UV-B response. We show here that uvr8-null mutants are 
      deficient in UV-B-induced photomorphogenesis and hypersensitive to UV-B stress, 
      whereas overexpression of UVR8 results in enhanced UV-B photomorphogenesis, 
      acclimation and tolerance to UV-B stress. By using sun simulators, we provide 
      evidence at the physiological level that UV-B acclimation mediated by the 
      UV-B-specific photoregulatory pathway is indeed required for survival in 
      sunlight. At the molecular level, we demonstrate that the wild type but not the 
      mutant UVR8 and COP1 proteins directly interact in a UV-B-dependent, rapid manner 
      in planta. These data collectively suggest that UV-B-specific interaction of COP1 
      and UVR8 in the nucleus is a very early step in signalling and responsible for 
      the plant's coordinated response to UV-B ensuring UV-B acclimation and protection 
      in the natural environment.
FAU - Favory, Jean-Jacques
AU  - Favory JJ
AD  - Faculty of Biology, Institute of Biology II, University of Freiburg, Freiburg, 
      Germany.
FAU - Stec, Agnieszka
AU  - Stec A
FAU - Gruber, Henriette
AU  - Gruber H
FAU - Rizzini, Luca
AU  - Rizzini L
FAU - Oravecz, Attila
AU  - Oravecz A
FAU - Funk, Markus
AU  - Funk M
FAU - Albert, Andreas
AU  - Albert A
FAU - Cloix, Catherine
AU  - Cloix C
FAU - Jenkins, Gareth I
AU  - Jenkins GI
FAU - Oakeley, Edward J
AU  - Oakeley EJ
FAU - Seidlitz, Harald K
AU  - Seidlitz HK
FAU - Nagy, Ferenc
AU  - Nagy F
FAU - Ulm, Roman
AU  - Ulm R
LA  - eng
GR  - BB/D019281/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090122
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (Uvr8 protein, Arabidopsis)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Acclimatization
MH  - Arabidopsis/*physiology
MH  - Arabidopsis Proteins/genetics/*physiology
MH  - Chromosomal Proteins, Non-Histone/genetics/*physiology
MH  - Gene Expression Regulation, Plant
MH  - Hypocotyl/growth & development/physiology
MH  - Mutation
MH  - Protein Binding
MH  - Signal Transduction/physiology
MH  - Stress, Physiological
MH  - Sunlight
MH  - Ubiquitin-Protein Ligases
MH  - *Ultraviolet Rays
PMC - PMC2657586
EDAT- 2009/01/24 09:00
MHDA- 2009/03/28 09:00
PMCR- 2010/03/04
CRDT- 2009/01/24 09:00
PHST- 2008/09/30 00:00 [received]
PHST- 2009/01/05 00:00 [accepted]
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2010/03/04 00:00 [pmc-release]
AID - emboj20094 [pii]
AID - 10.1038/emboj.2009.4 [doi]
PST - ppublish
SO  - EMBO J. 2009 Mar 4;28(5):591-601. doi: 10.1038/emboj.2009.4. Epub 2009 Jan 22.