PMID- 19165227
OWN - NLM
STAT- MEDLINE
DCOM- 20090403
LR  - 20211020
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 9
IP  - 2
DP  - 2009 Feb
TI  - RUNX proteins in transcription factor networks that regulate T-cell lineage 
      choice.
PG  - 106-15
LID - 10.1038/nri2489 [doi]
AB  - Recent research has uncovered complex transcription factor networks that control 
      the processes of T-cell development and differentiation. RUNX (runt-related 
      transcription factor) proteins are among the many factors that have crucial roles 
      in these networks. In this Review, we examine the mechanisms by which RUNX 
      complexes act together with other transcription factors, such as Th-POK 
      (T-helper-inducing POZ/Kruppel-like factor) and GATA-binding protein 3 (GATA3) in 
      determining the CD4/CD8 lineage choice of developing thymocytes. In addition, we 
      discuss evidence indicating that RUNX complexes are also involved in the 
      differentiation of effector T-cell subsets and that the molecular mechanisms by 
      which RUNX proteins regulate T-cell fate decisions are conserved between the 
      thymus and periphery.
FAU - Collins, Amelie
AU  - Collins A
AD  - The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular 
      Medicine, Howard Hughes Medical Institute, New York University School of 
      Medicine, 540 First Avenue, New York, New York 10016, USA.
FAU - Littman, Dan R
AU  - Littman DR
FAU - Taniuchi, Ichiro
AU  - Taniuchi I
LA  - eng
GR  - T32 GM007308/GM/NIGMS NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Core Binding Factor alpha Subunits)
RN  - 0 (Cytokines)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Th-POK protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
CIN - Nat Rev Immunol. 2009 Feb;9(2):81-2. PMID: 19172726
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cell Lineage/*genetics/immunology
MH  - Core Binding Factor alpha Subunits/genetics/*metabolism
MH  - Cytokines/biosynthesis
MH  - GATA3 Transcription Factor/genetics/metabolism
MH  - Gene Expression Regulation
MH  - *Gene Regulatory Networks
MH  - Humans
MH  - Lymphopoiesis/*genetics
MH  - Thymus Gland/immunology
MH  - Transcription Factors/genetics/metabolism
PMC - PMC4231139
MID - NIHMS637521
EDAT- 2009/01/24 09:00
MHDA- 2009/04/04 09:00
PMCR- 2014/11/13
CRDT- 2009/01/24 09:00
PHST- 2009/01/24 09:00 [entrez]
PHST- 2009/01/24 09:00 [pubmed]
PHST- 2009/04/04 09:00 [medline]
PHST- 2014/11/13 00:00 [pmc-release]
AID - nri2489 [pii]
AID - 10.1038/nri2489 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2009 Feb;9(2):106-15. doi: 10.1038/nri2489.