PMID- 19166016
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20240109
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 33
IP  - 19
DP  - 2008 Oct
TI  - [PTP1B inhibitory activities of bromophenol derivatives from algae].
PG  - 2238-40
AB  - OBJECTIVE: To study the protein tyrosine phosphatase-1B (PTP1B) inhibitory 
      activity of natural products from algae aiming at searching for new way for the 
      treatment of type 2 diabetes mellitus (T2DM) and obesity. METHOD: Bromophenols 
      derivatives from algae were screened against the PTP1B by the colorimetric assay 
      with GST/PTP1B fusion protein. The Me2SO was distributed as the full enzyme 
      activity, and Na3VO4 (IC50 2 micromol L(-1)) was distributed as the positive 
      control. Inhibition rate was assayed and IC50 were calculated by LOGIT method. 
      RESULT: Three bromophenols from Rhodomela confervoides and Leathesia nana, 3, 
      4-dibromo-5-(methoxymethyl)-1, 2-benzenediol (1), 2-methyl-3-(2, 3-dibromo4, 
      5-dihydroxy)-propylaldehyde (2) and 3-(2, 3-dibromo-4, 
      5-dihydroxy-phenyl)-4-bromo-5, 6-dihydroxy-1, 3-dihydroiso-benzofuran (3) showed 
      significant inhibitory activity against PTP1B. IC50 values were 3.4 +/- micromol 
      L(-1), 4.5 micromol L(-1) and 2.8 micromol L(-1), respectively. CONCLUSION: The 
      results prove that three bromophenol derivatives from algae with significant 
      inhibitory activity against PTP1B were potential and effective therapeutic agents 
      for treatment of T2DM and obesity.
FAU - Shi, Da-Yong
AU  - Shi DY
AD  - Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
FAU - Xu, Feng
AU  - Xu F
FAU - Li, Jing
AU  - Li J
FAU - Guo, Shu-Ju
AU  - Guo SJ
FAU - Su, Hua
AU  - Su H
FAU - Han, Li-Jun
AU  - Han LJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Phenols)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
SB  - IM
MH  - Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Eukaryota/*chemistry
MH  - Phaeophyceae/chemistry
MH  - Phenols/*chemistry/*therapeutic use
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1/*antagonists & inhibitors
MH  - Rhodophyta/chemistry
EDAT- 2009/01/27 09:00
MHDA- 2009/05/09 09:00
CRDT- 2009/01/27 09:00
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2238-40.