PMID- 19166026
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20120625
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 18
DP  - 2008 Sep
TI  - [Effect of CDK2 on proliferation in laryngeal squamous cell carcinoma].
PG  - 824-6
AB  - OBJECTIVE: To investigate the role of CDK2 in the development of DNA heteroploid 
      in laryngeal squamous cell carcinoma (LSCC). METHOD: Fifty specimens of LSCC, 
      twelve specimens of atypical hyperplasia and thirty specimens of vocal cord polyp 
      were obtain during operation. Centrosome were detected by anti tubulin 
      antibodies. Immunohistochemical method was used to analyze the protein expression 
      of CDK2 and gamma-tubulin. RESULT: The positive rate of CDK2 and gamma-tubulin in 
      LSCC were 68.0% (34/50) and 78.0% (10/15), all of them were significant higher 
      than those in the vocal cord polyp (P<0.05). Expression of CDK2 in LSCC was 
      positively association with expression of gamma-tubulin. CONCLUSION: This 
      experiment indicated that overexpression of CDK2 was strongly correlated with 
      abnormal proliferation in LSCC, and it may be a valuable marker for the diagnosis 
      and therapy of LSCC.
FAU - Zhang, Haili
AU  - Zhang H
AD  - Department of Otolaryngology, the First Hospital of Medical University, Taiyuan, 
      030001, China. zhanghaili1975@yahoo.com.cn
FAU - Wang, Binquan
AU  - Wang B
FAU - Liu, Rong
AU  - Liu R
FAU - Wen, Shuxin
AU  - Wen S
FAU - Huangfu, Hui
AU  - Huangfu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.7.11.22 (CDK2 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cell Proliferation
MH  - Cyclin-Dependent Kinase 2/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
EDAT- 2009/01/27 09:00
MHDA- 2011/06/24 06:00
CRDT- 2009/01/27 09:00
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Sep;22(18):824-6.