PMID- 19166697
OWN - NLM
STAT- MEDLINE
DCOM- 20090211
LR  - 20090126
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 103
IP  - 3
DP  - 2009 Feb 1
TI  - Usefulness of Type D personality and kidney dysfunction as predictors of 
      interpatient variability in inflammatory activation in chronic heart failure.
PG  - 399-404
LID - 10.1016/j.amjcard.2008.09.096 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha), soluble TNF-alpha receptors 1 and 2 
      (sTNFR1/2), and interleukin (IL)-6 are powerful predictors of mortality in 
      chronic heart failure (CHF). Little is known, however, about the origins of 
      proinflammatory cytokine production or the determinants of substantial 
      interpatient variability in inflammatory activation. We prospectively examined 
      kidney dysfunction and Type D personality (tendency to experience and inhibit 
      emotional distress) as predictors of interpatient variability in these markers of 
      inflammatory activation. At baseline, 125 patients with CHF were assessed for 
      kidney dysfunction and Type D. Serum levels of proinflammatory cytokines 
      (TNF-alpha, sTNFR1, sTNFR2, IL-6), the anti-inflammatory cytokines IL-10, and 
      IL-1 receptor antagonist were measured at 1-year follow-up. Type D patients had 
      higher levels of sTNFR1 (p = 0.009) and sTNFR2 (p = 0.001) and lower levels of 
      IL-10 (p = 0.006) than patients without Type D and kidney dysfunction. Patients 
      with kidney dysfunction also had elevated levels of sTNFR1 and sTNFR2 (p 
      <0.0001), but their IL-10 level was not decreased. Type D personality and kidney 
      dysfunction predicted increased sTNFR1/IL-10 and sTNFR2/IL-10 ratios (p < or 
      =0.007); Type D also predicted an increased IL-6/IL-10 ratio (p = 0.013). Other 
      predictors were spironolactone and older age. After adjusting for these 
      variables, the odds for elevated ratios (highest 20%) were still increased in 
      Type D patients (all odd ratios >3.00). In conclusion, Type D personality and 
      kidney dysfunction independently predicted unfavorable cytokine profiles in 
      patients with CHF and may enhance our understanding of interpatient variability 
      in inflammatory activation in these patients.
FAU - Denollet, Johan
AU  - Denollet J
AD  - Center of Research on Psychology in Somatic diseases (CoRPS), Tilburg University, 
      Tilburg, The Netherlands. denollet@uvt.nl
FAU - Schiffer, Angelique A
AU  - Schiffer AA
FAU - Kwaijtaal, Martijn
AU  - Kwaijtaal M
FAU - Hooijkaas, Herbert
AU  - Hooijkaas H
FAU - Hendriks, Eric H
AU  - Hendriks EH
FAU - Widdershoven, Jos W
AU  - Widdershoven JW
FAU - Kupper, Nina
AU  - Kupper N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081121
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Aged
MH  - Cytokines/*blood
MH  - Female
MH  - Heart Failure/blood/complications/*immunology/*psychology
MH  - Humans
MH  - Inflammation
MH  - Interleukin-10/blood
MH  - Interleukin-6/blood
MH  - Kidney Diseases/*complications
MH  - Male
MH  - Middle Aged
MH  - *Personality
MH  - Receptors, Interleukin-1/antagonists & inhibitors
MH  - Receptors, Tumor Necrosis Factor, Type I/blood
MH  - Receptors, Tumor Necrosis Factor, Type II/blood
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2009/01/27 09:00
MHDA- 2009/02/12 09:00
CRDT- 2009/01/27 09:00
PHST- 2008/07/23 00:00 [received]
PHST- 2008/09/23 00:00 [revised]
PHST- 2008/09/23 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
AID - S0002-9149(08)01714-1 [pii]
AID - 10.1016/j.amjcard.2008.09.096 [doi]
PST - ppublish
SO  - Am J Cardiol. 2009 Feb 1;103(3):399-404. doi: 10.1016/j.amjcard.2008.09.096. Epub 
      2008 Nov 21.