PMID- 19166929
OWN - NLM
STAT- MEDLINE
DCOM- 20090603
LR  - 20211020
IS  - 1873-3913 (Electronic)
IS  - 0898-6568 (Linking)
VI  - 21
IP  - 6
DP  - 2009 Jun
TI  - Mammalian target of rapamycin complex 1: signalling inputs, substrates and 
      feedback mechanisms.
PG  - 827-35
LID - 10.1016/j.cellsig.2009.01.012 [doi]
AB  - The mammalian target of rapamycin (mTOR) signalling pathway is implicated in the 
      pathogenesis of a number of cancers and inherited hamartoma syndromes which have 
      led to mTOR inhibitors, such as rapamycin, being tested in clinical trials. 
      Knowledge of the mTOR pathway is rapidly expanding. This review provides an 
      update on the most recent additions to the mTOR pathway with particular emphasis 
      on mTORC1 signalling. mTORC1 signalling is classically known for its role in 
      regulating cell growth and proliferation through modulation of protein synthesis. 
      Recent research has identified novel mTORC1 cell signalling mechanisms that 
      modulate mitochondrial biogenesis, hypoxia signalling and cell cycle progression 
      and uncovered novel mTORC1 targets; YY1, HIF and SGK1. It is unsurprising that 
      regulation of mTORC1 is multifaceted with many positive and negative signalling 
      inputs. We discuss the recent advances that have been made to determine the 
      upstream mechanisms that control mTORC1 through hypoxia, energy sensing and 
      nutrient signalling. Also discussed are current findings that have unravelled a 
      series of novel mTORC1-associated proteins that directly control the activity of 
      mTORC1 and include PRAS40, FKBP38, Rag GTPases and RalA.
FAU - Dunlop, E A
AU  - Dunlop EA
AD  - Institute of Medical Genetics, Cardiff University, Heath Park, Cardiff, Wales, 
      UK.
FAU - Tee, A R
AU  - Tee AR
LA  - eng
GR  - 06-0914/AICR_/Worldwide Cancer Research/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090108
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Feedback, Physiological
MH  - Humans
MH  - Models, Biological
MH  - *Signal Transduction
MH  - Substrate Specificity
MH  - Transcription Factors/chemistry/*metabolism
RF  - 134
EDAT- 2009/01/27 09:00
MHDA- 2009/06/06 09:00
CRDT- 2009/01/27 09:00
PHST- 2008/12/09 00:00 [received]
PHST- 2009/01/02 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/06/06 09:00 [medline]
AID - S0898-6568(09)00016-3 [pii]
AID - 10.1016/j.cellsig.2009.01.012 [doi]
PST - ppublish
SO  - Cell Signal. 2009 Jun;21(6):827-35. doi: 10.1016/j.cellsig.2009.01.012. Epub 2009 
      Jan 8.