PMID- 19167082
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20220330
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 116
IP  - 3
DP  - 2009 Mar
TI  - Photoreceptor layer thinning over drusen in eyes with age-related macular 
      degeneration imaged in vivo with spectral-domain optical coherence tomography.
PG  - 488-496.e2
LID - 10.1016/j.ophtha.2008.10.006 [doi]
AB  - PURPOSE: Detect changes in the neurosensory retina using spectral-domain optical 
      coherence tomography (SD OCT) imaging over drusen in age-related macular 
      degeneration (AMD). Quantitative imaging biomarkers may aid in defining risk of 
      disease progression. DESIGN: Cross-sectional, case-control study evaluating SD 
      OCT testing in AMD. PARTICIPANTS AND CONTROLS: Seventeen eyes of 12 subjects with 
      nonneovascular AMD and drusen and 17 eyes of 10 age-matched control subjects. 
      METHODS: Spectral-domain OCT imaging across the fovea in the study eye with 
      multiple 10- to 12-mm scans of 1000 A scans each. MAIN OUTCOME MEASURES: In 
      summed SD OCT scans, the height of individual retinal layers either over drusen 
      or at corresponding locations in the control eye and qualitative changes in 
      retinal layers over drusen. Secondary measures included photoreceptor layer (PRL) 
      area, inner retinal area, and retinal pigment epithelium (RPE)/drusen area. 
      RESULTS: The PRL was thinned over 97% of drusen, average PRL thickness was 
      reduced by 27.5% over drusen compared with over a similar location in controls, 
      and the finding of a difference was valid and significant (P=0.004). 
      Photoreceptor outer segments were absent over at least 1 druse in 47% of eyes. 
      Despite thinning of the PRL, inner retinal thickness remained unchanged. We 
      observed 2 types of hyperreflective abnormalities in the neurosensory retina over 
      drusen. Distinct hyperreflective speckled patterns occurred over drusen in 41% of 
      AMD eyes and never in control eyes. A prominent hyperreflective haze was present 
      in the photoreceptor nuclear layer over drusen in 67% of AMD eyes and more subtly 
      in the photoreceptor nuclear layer in 18% of control eyes (no drusen). 
      CONCLUSIONS: With SD OCT as used in this study, we can easily detect and measure 
      changes in PRL over drusen. Decreased PRL thickness over drusen suggests a 
      degenerative process, with cell loss leading to decreased visual function. The 
      hyperreflective foci overlying drusen are likely to represent progression of 
      disease RPE cell migration into the retina and possible photoreceptor 
      degeneration or glial scar formation. A longitudinal study using SD OCT to 
      examine and measure the neurosensory retina over drusen will resolve the timeline 
      of degenerative changes relative to druse formation.
FAU - Schuman, Stefanie G
AU  - Schuman SG
AD  - Duke University Medical Center, Department of Ophthalmology, Durham, North 
      Carolina 27710, USA.
FAU - Koreishi, Anjum F
AU  - Koreishi AF
FAU - Farsiu, Sina
AU  - Farsiu S
FAU - Jung, Sin-ho
AU  - Jung SH
FAU - Izatt, Joseph A
AU  - Izatt JA
FAU - Toth, Cynthia A
AU  - Toth CA
LA  - eng
GR  - R21 EY017393/EY/NEI NIH HHS/United States
GR  - UL1 RR024128-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
GR  - R21 EY017393-02/EY/NEI NIH HHS/United States
GR  - R21 EY017393-01/EY/NEI NIH HHS/United States
GR  - 1 UL1 RR024128-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090122
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retinal Drusen/*diagnosis
MH  - *Tomography, Optical Coherence
PMC - PMC2695995
MID - NIHMS98956
EDAT- 2009/01/27 09:00
MHDA- 2009/03/21 09:00
PMCR- 2010/03/01
CRDT- 2009/01/27 09:00
PHST- 2008/02/23 00:00 [received]
PHST- 2008/10/07 00:00 [revised]
PHST- 2008/10/07 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
PHST- 2010/03/01 00:00 [pmc-release]
AID - S0161-6420(08)01026-9 [pii]
AID - 10.1016/j.ophtha.2008.10.006 [doi]
PST - ppublish
SO  - Ophthalmology. 2009 Mar;116(3):488-496.e2. doi: 10.1016/j.ophtha.2008.10.006. 
      Epub 2009 Jan 22.