PMID- 19167168
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20131121
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 34
IP  - 5
DP  - 2009 Jun
TI  - Maternal deprivation by early weaning increases corticosterone and decreases 
      hippocampal BDNF and neurogenesis in mice.
PG  - 762-72
LID - 10.1016/j.psyneuen.2008.12.009 [doi]
AB  - We previously demonstrated that early weaning increases anxiety and 
      neuroendocrine stress responses in rats and mice. In addition, early-weaned mice 
      show precocious myelin formation, especially in the amygdala, suggesting that 
      these mice are vulnerable to psychological stress. In the present experiments, we 
      examined corticosterone response after early weaning and how early weaning 
      affects hippocampal neurotrophic factor and neurogenesis, which have been linked 
      to depressive behavior in human and animals models. When the mice were weaned at 
      PD14, both male and female mice showed higher corticosterone levels up to 48h 
      after weaning. In contrast, after standard weaning, corticosterone levels 
      returned to the baseline within 2h. Early-weaned males, but not females, had less 
      brain-derived neurotrophic factor (BDNF) protein in the hippocampus at 3 weeks of 
      age than standard-weaned mice. Neural stem cells were labeled with 
      bromodeoxyuridine (BrdU) injections at 2, 3, or 5 weeks of age, and assayed at 3, 
      5, and 8 weeks of age, respectively. Early-weaned males had fewer BrdU 
      immunoreactive cells in the dentate gyrus at 3, 5, and 8 weeks. In early-weaned 
      females, fewer BrdU-positive cells were observed only at 5 weeks. Double-staining 
      with BrdU and the neuron markers NeuN and Tuj1 demonstrated that neurogenesis was 
      lower in early-weaned mice at 5 weeks of age. These results suggest that lack of 
      mother-infant interaction during the late lactation period leads to an increase 
      in corticosterone synthesis for 2 days and a decrease in BDNF synthesis in males; 
      moreover, this lack of interaction transiently inhibits hippocampal cell 
      proliferation and survival in both males and females, although the effects were 
      more pronounced in males.
FAU - Kikusui, Takefumi
AU  - Kikusui T
AD  - Veterinary Ethology, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, 
      Japan. kikusui@azabu-u.ac.jp
FAU - Ichikawa, Sozo
AU  - Ichikawa S
FAU - Mori, Yuji
AU  - Mori Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090122
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Animals, Suckling
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Proliferation
MH  - Cell Survival/physiology
MH  - Corticosterone/*blood
MH  - Female
MH  - Hippocampus/*metabolism
MH  - Male
MH  - *Maternal Deprivation
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurogenesis/*physiology
MH  - Sex Characteristics
MH  - Time Factors
MH  - *Weaning
EDAT- 2009/01/27 09:00
MHDA- 2009/08/26 09:00
CRDT- 2009/01/27 09:00
PHST- 2008/05/09 00:00 [received]
PHST- 2008/12/05 00:00 [revised]
PHST- 2008/12/15 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
AID - S0306-4530(08)00335-1 [pii]
AID - 10.1016/j.psyneuen.2008.12.009 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2009 Jun;34(5):762-72. doi: 
      10.1016/j.psyneuen.2008.12.009. Epub 2009 Jan 22.