PMID- 19167700
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20211028
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 66
IP  - 3
DP  - 2009 Aug 1
TI  - Changes in gyrification over 4 years in bipolar disorder and their association 
      with the brain-derived neurotrophic factor valine(66) methionine variant.
PG  - 293-7
LID - 10.1016/j.biopsych.2008.12.006 [doi]
AB  - BACKGROUND: Evidence suggests that structural brain changes occur over time in 
      bipolar disorder but few studies have examined this longitudinally. Additional 
      work implicates brain-derived neurotrophic factor (BDNF) valine 
      (val)(66)methionine (met) variant in these changes. The present study examined 
      longitudinal trends in prefrontal gyrification index (GI) in bipolar disorder and 
      the effect of BDNF genotype. METHODS: Eighteen patients with bipolar I disorder 
      and 18 control subjects underwent magnetic resonance imaging at study entry and 
      after 4 years. Prefrontal GI was computed as the ratio of folded inner contour to 
      exposed outer contour. RESULTS: Ventral and dorsal GI decreased significantly 
      with time in both cohorts; the rate did not differ for bipolar patients. Within 
      the bipolar cohort, individuals with one or more BDNF met alleles showed greater 
      losses in GI, an effect that correlated with gray matter loss in the left 
      hemisphere. CONCLUSIONS: Gyrification index may be sensitive to atrophy, as well 
      as being a neurodevelopmental measure. While the loss of prefrontal gyrification 
      over time is not accelerated in bipolar disorder, a greater rate of loss is 
      associated with the possession of one or more BDNF met alleles.
FAU - Mirakhur, Ajay
AU  - Mirakhur A
AD  - Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh 
      Hospital, Edinburgh EH10 5HF, United Kingdom. a.mirakhur@doctors.org.uk
FAU - Moorhead, T William J
AU  - Moorhead TW
FAU - Stanfield, Andrew C
AU  - Stanfield AC
FAU - McKirdy, James
AU  - McKirdy J
FAU - Sussmann, Jessika E D
AU  - Sussmann JE
FAU - Hall, Jeremy
AU  - Hall J
FAU - Lawrie, Stephen M
AU  - Lawrie SM
FAU - Johnstone, Eve C
AU  - Johnstone EC
FAU - McIntosh, Andrew M
AU  - McIntosh AM
LA  - eng
GR  - G0600429/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090123
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Bipolar Disorder/*genetics/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Disease Progression
MH  - Electronic Data Processing/methods
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Prefrontal Cortex/*pathology
MH  - Valine/*genetics
EDAT- 2009/01/27 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/01/27 09:00
PHST- 2008/09/05 00:00 [received]
PHST- 2008/11/18 00:00 [revised]
PHST- 2008/12/06 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - S0006-3223(08)01568-0 [pii]
AID - 10.1016/j.biopsych.2008.12.006 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2009 Aug 1;66(3):293-7. doi: 10.1016/j.biopsych.2008.12.006. 
      Epub 2009 Jan 23.