PMID- 19167831
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20211020
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 34
IP  - 6
DP  - 2009 Jul
TI  - A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes 
      mellitus.
PG  - 815-21
LID - 10.1016/j.psyneuen.2008.12.010 [doi]
AB  - There is emerging evidence from healthy individuals, as well as direct and 
      indirect evidence from psychiatric and neurological patients with disease-related 
      hippocampal atrophy, linking the cortisol awakening response (CAR) to hippocampal 
      volume. Type 2 diabetes mellitus (T2DM) is a metabolic disease that is also 
      accompanied by hippocampal atrophy, and therefore can serve as a model for 
      ascertaining the relationship between CAR and hippocampal volume. We contrasted a 
      group of 18 individuals with T2DM with 12 matched controls on MRI-based 
      hippocampal volume and salivary diurnal cortisol profile including CAR. 
      Individuals with T2DM had smaller hippocampal volumes and exhibited a blunting of 
      the CAR relative to controls, while diurnal cortisol was not affected. Across all 
      subjects, fasting insulin and hippocampal volume were associated with the CAR, 
      independent of diagnosis. Our findings support the hypothesis that hippocampal 
      integrity is an important predictor of the CAR.
FAU - Bruehl, Hannah
AU  - Bruehl H
AD  - NYU School of Medicine, Department of Psychiatry, New York, NY 10016, USA.
FAU - Wolf, Oliver T
AU  - Wolf OT
FAU - Convit, Antonio
AU  - Convit A
LA  - eng
GR  - M01 RR000096/RR/NCRR NIH HHS/United States
GR  - DK 064087/DK/NIDDK NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - R01 DK064087/DK/NIDDK NIH HHS/United States
GR  - M01 RR00096/RR/NCRR NIH HHS/United States
GR  - P30-AG-08051/AG/NIA NIH HHS/United States
GR  - R01 DK064087-05/DK/NIDDK NIH HHS/United States
GR  - M01 RR000096-47/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090124
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Arousal/*physiology
MH  - Atrophy/complications
MH  - Brain/pathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications/*metabolism/pathology/physiopathology
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Hydrocortisone/analysis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Saliva/chemistry/metabolism
PMC - PMC2774914
MID - NIHMS114160
COIS- Conflict of interest The authors have no real or apparent conflict of interest.
EDAT- 2009/01/27 09:00
MHDA- 2009/08/26 09:00
PMCR- 2009/11/09
CRDT- 2009/01/27 09:00
PHST- 2008/08/20 00:00 [received]
PHST- 2008/10/24 00:00 [revised]
PHST- 2008/12/16 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
PHST- 2009/11/09 00:00 [pmc-release]
AID - S0306-4530(08)00337-5 [pii]
AID - 10.1016/j.psyneuen.2008.12.010 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2009 Jul;34(6):815-21. doi: 
      10.1016/j.psyneuen.2008.12.010. Epub 2009 Jan 24.