PMID- 19169494
OWN - NLM
STAT- MEDLINE
DCOM- 20091007
LR  - 20190917
IS  - 1677-9487 (Electronic)
IS  - 0004-2730 (Linking)
VI  - 52
IP  - 8
DP  - 2008 Nov
TI  - Possible association between Carney complex and multiple endocrine neoplasia type 
      1 phenotypes.
PG  - 1356-61
LID - S0004-27302008000800025 [pii]
AB  - Carney Complex (CNC) and Multiple Endocrine Neoplasia type 1 (MEN1) are forms of 
      multiple endocrine neoplasia of dominant autosomal inheritance. Diagnosis of CNC 
      occurs when two major criteria (lentiginoses, primary pigmented nodular 
      adrenocortical disease, cardiac and cutaneous myxomas, acromegaly, testicular 
      neoplasias, thyroid cancer) are observed and/or a major criterion associated with 
      a supplementary criterion (affected relative, PRKAR1A gene mutation) occurs. On 
      the other hand, diagnosis for MEN1 occurs through detection of two or more tumors 
      located at the pituitary gland, parathyroid and/or pancreatic cells. The present 
      case describes a 55 year-old male patient, diagnosed with acromegaly, primary 
      hyperparathyroidism and papillary thyroid cancer, exhibiting components that meet 
      the diagnostic criteria of both conditions described. Despite the occurrence of 
      only one sporadic association or the acromegaly per se being responsible for the 
      papillary cancer, new molecular mechanisms may not be ruled out.
FAU - Nunes, Vania S
AU  - Nunes VS
AD  - Department of Clinical Medicine, Universidade Estadual Paulista, Botucatu, SP, 
      Brazil. nunesvania2003@yahoo.com.br
FAU - Chang, Claudia V
AU  - Chang CV
FAU - Mazeto, Glaucia M F S
AU  - Mazeto GM
FAU - Marques, Mariangela E A
AU  - Marques ME
FAU - Castro, Ana Valeria B
AU  - Castro AV
FAU - Nogueira, Celia R
AU  - Nogueira CR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Endocrinol Metabol
JT  - Arquivos brasileiros de endocrinologia e metabologia
JID - 0403437
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Acromegaly/diagnosis
MH  - Carcinoma, Papillary/diagnosis
MH  - Humans
MH  - Hyperparathyroidism, Primary/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Mutation
MH  - Pedigree
MH  - Phenotype
MH  - Proto-Oncogene Proteins/genetics
MH  - Thyroid Neoplasms/diagnosis
EDAT- 2009/01/27 09:00
MHDA- 2009/10/08 06:00
CRDT- 2009/01/27 09:00
PHST- 2008/10/05 00:00 [received]
PHST- 2008/11/03 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/10/08 06:00 [medline]
AID - S0004-27302008000800025 [pii]
AID - 10.1590/s0004-27302008000800025 [doi]
PST - ppublish
SO  - Arq Bras Endocrinol Metabol. 2008 Nov;52(8):1356-61. doi: 
      10.1590/s0004-27302008000800025.