PMID- 19169748
OWN - NLM
STAT- MEDLINE
DCOM- 20091216
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 23
IP  - 9
DP  - 2009 Sep
TI  - The use of medication after laparoscopic antireflux surgery.
PG  - 1938-46
LID - 10.1007/s00464-008-0271-8 [doi]
AB  - BACKGROUND: Laparoscopic antireflux surgery (LARS) significantly improves 
      symptoms of gastro-esophageal reflux disease (GERD) and quality of life. 
      Nevertheless, 14-62% of patients report using antisecretory medication after 
      surgery, although only a tiny percentage has proven recurrence of GERD. We sought 
      to determine symptoms of GERD, quality of life, and use of medication before and 
      after LARS, and to compare our findings with those from previous studies. 
      METHODS: Five hundred fifty-three patients with GERD who underwent LARS were 
      evaluated before and at 1 year after surgery. After surgery, multidisciplinary 
      follow-up care was provided for all patients by surgeons, psychologists, 
      dieticians, and speech therapists. RESULTS: Symptoms of GERD and quality of life 
      improved significantly and only 4.2% of patients still required medication after 
      surgery [proton pump inhibitors (PPI) (98.4 vs. 2.2%; p < 0.01), prokinetics (9.6 
      vs. 1.1%; p < 0.01), and psychiatric medication (8 vs. 1.6%; p < 0.01)]. 
      CONCLUSION: LARS significantly reduced medication use at 1-year follow-up. 
      However, these effects might be attributed, in part, to the multidisciplinary 
      follow-up care. Further studies are therefore required to investigate which 
      patients may benefit from multidisciplinary follow-up care and whether its 
      selective application may reduce the need for medication after LARS.
FAU - Ciovica, Ruxandra
AU  - Ciovica R
AD  - Department of Surgery, General Hospital of Krems, Mitterweg 10, 3500, Krems, 
      Austria.
FAU - Riedl, Otto
AU  - Riedl O
FAU - Neumayer, Christoph
AU  - Neumayer C
FAU - Lechner, Wolfgang
AU  - Lechner W
FAU - Schwab, Gerhard P
AU  - Schwab GP
FAU - Gadenstatter, Michael
AU  - Gadenstatter M
LA  - eng
PT  - Journal Article
DEP - 20090124
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Surg Endosc. 2010 Sep;24(9):2363-4. PMID: 20174932
CIN - Surg Endosc. 2010 Sep;24(9):2358. PMID: 20186435
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Anxiety Agents/*therapeutic use
MH  - Antidepressive Agents/*therapeutic use
MH  - Combined Modality Therapy
MH  - Drug Utilization/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - *Fundoplication
MH  - Gastroesophageal Reflux/*drug therapy/surgery
MH  - Gastrointestinal Agents/*therapeutic use
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Patient Care Team
MH  - Postoperative Period
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Quality of Life
MH  - Recurrence
MH  - Young Adult
EDAT- 2009/01/27 09:00
MHDA- 2009/12/17 06:00
CRDT- 2009/01/27 09:00
PHST- 2008/06/04 00:00 [received]
PHST- 2008/11/05 00:00 [accepted]
PHST- 2009/01/27 09:00 [entrez]
PHST- 2009/01/27 09:00 [pubmed]
PHST- 2009/12/17 06:00 [medline]
AID - 10.1007/s00464-008-0271-8 [doi]
PST - ppublish
SO  - Surg Endosc. 2009 Sep;23(9):1938-46. doi: 10.1007/s00464-008-0271-8. Epub 2009 
      Jan 24.