PMID- 19170664
OWN - NLM
STAT- MEDLINE
DCOM- 20090707
LR  - 20220410
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 33
IP  - 4
DP  - 2009 Apr
TI  - Association between Val66Met brain-derived neurotrophic factor (BDNF) gene 
      polymorphism and post-treatment relapse in alcohol dependence.
PG  - 693-702
LID - 10.1111/j.1530-0277.2008.00886.x [doi]
AB  - BACKGROUND: The purpose of this study was to examine relationships between 
      genetic markers of central serotonin (5-HT) and dopamine function, and risk for 
      post-treatment relapse, in a sample of alcohol-dependent patients. METHODS: The 
      study included 154 patients from addiction treatment programs in Poland, who met 
      DSM-IV criteria for alcohol dependence. After assessing demographics, severity of 
      alcohol use, suicidality, impulsivity, depression, hopelessness, and severity of 
      alcohol use at baseline, patients were followed for approximately 1 year to 
      evaluate treatment outcomes. Genetic polymorphisms in several genes (TPH2, 
      SLC6A4, HTR1A, HTR2A, COMT, and BDNF) were tested as predictors of relapse 
      (defined as any drinking during follow-up) while controlling for baseline 
      measures. RESULTS: Of 154 eligible patients, 123 (80%) completed follow-up and 
      48% (n = 59) of these individuals relapsed. Patients with the Val allele in the 
      Val66Met BDNF polymorphism and the Met allele in the Val158Met COMT polymorphism 
      were more likely to relapse. Only the BDNF Val/Val genotype predicted 
      post-treatment relapse [odds ratio (OR) = 2.62; p = 0.019], and time to relapse 
      (OR = 2.57; p = 0.002), after adjusting for baseline measures and other 
      significant genetic markers. When the analysis was restricted to patients with a 
      family history of alcohol dependence (n = 73), the associations between the BDNF 
      Val/Val genotype and relapse (OR = 5.76, p = 0.0045) and time to relapse (hazard 
      ratio = 4.93, p = 0.001) were even stronger. CONCLUSIONS: The Val66Met BDNF gene 
      polymorphism was associated with a higher risk and earlier occurrence of relapse 
      among patients treated for alcohol dependence. The study suggests a relationship 
      between genetic markers and treatment outcomes in alcohol dependence. Because a 
      large number of statistical tests were conducted for this study and the 
      literature on genetics and relapse is so novel, the results should be considered 
      as hypothesis generating and need to be replicated in independent studies.
FAU - Wojnar, Marcin
AU  - Wojnar M
AD  - Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA. 
      mwojnar@umich.edu
FAU - Brower, Kirk J
AU  - Brower KJ
FAU - Strobbe, Stephen
AU  - Strobbe S
FAU - Ilgen, Mark
AU  - Ilgen M
FAU - Matsumoto, Halina
AU  - Matsumoto H
FAU - Nowosad, Izabela
AU  - Nowosad I
FAU - Sliwerska, Elzbieta
AU  - Sliwerska E
FAU - Burmeister, Margit
AU  - Burmeister M
LA  - eng
GR  - R21AA016104/AA/NIAAA NIH HHS/United States
GR  - D43 TW005818/TW/FIC NIH HHS/United States
GR  - R21 AA016104-02/AA/NIAAA NIH HHS/United States
GR  - D43-TW05818/TW/FIC NIH HHS/United States
GR  - D43 TW007569/TW/FIC NIH HHS/United States
GR  - R21 AA016104/AA/NIAAA NIH HHS/United States
GR  - D43-TW007569/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090127
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Alcoholism/ethnology/*genetics/psychology
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Poland
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Recurrence
PMC - PMC2928673
MID - NIHMS160187
COIS- Conflict of Interest All authors declare that they have no conflicts of interest.
EDAT- 2009/01/28 09:00
MHDA- 2009/07/08 09:00
PMCR- 2010/08/26
CRDT- 2009/01/28 09:00
PHST- 2009/01/28 09:00 [entrez]
PHST- 2009/01/28 09:00 [pubmed]
PHST- 2009/07/08 09:00 [medline]
PHST- 2010/08/26 00:00 [pmc-release]
AID - ACER886 [pii]
AID - 10.1111/j.1530-0277.2008.00886.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2009 Apr;33(4):693-702. doi: 
      10.1111/j.1530-0277.2008.00886.x. Epub 2009 Jan 27.