PMID- 19171986
OWN - NLM
STAT- MEDLINE
DCOM- 20091116
LR  - 20220321
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 74
IP  - 6
DP  - 2008 Nov-Dec
TI  - Immune reconstitution inflammatory syndrome.
PG  - 619-21
AB  - BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical 
      deterioration in clinical status in a patient on antiretroviral treatment (ART) 
      despite satisfactory control of viral replication and improvement of CD4 count. 
      AIM: To study development of IRIS as a part of ART. METHODS: Hundred patients on 
      antiretroviral treatment were studied prospectively in the Department of Skin and 
      VD over a period of 2 years. Patients were asked to come if they developed any 
      symptoms or on a monthly basis. They were screened clinically and investigated 
      suitably for evidence of opportunistic infections. RESULTS: Out of 100 patients, 
      10 patients did not come for follow-up. Twenty (22.2%) out of the 90 patients 
      developed IRIS. Herpes zoster (HZ), herpes simplex virus (HSV), and tuberculosis 
      (TB) were the cases of IRIS seen in the present study. CONCLUSIONS: IRIS in terms 
      of HSV/TB is known to accelerate HIV disease progression. Hence early detection 
      and prompt treatment, along with continuation of highly active ART, are of utmost 
      importance.
FAU - Sharma, Ajay
AU  - Sharma A
AD  - Department of Skin and V.D., Medical College and SSG Hospital, Vadodara, India.
FAU - Makrandi, Smita
AU  - Makrandi S
FAU - Modi, Megha
AU  - Modi M
FAU - Sharma, Archana
AU  - Sharma A
FAU - Marfatia, Yogesh
AU  - Marfatia Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/adverse effects/therapeutic use
MH  - CD4 Lymphocyte Count/methods
MH  - Follow-Up Studies
MH  - HIV Infections/complications/drug therapy/pathology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/chemically 
      induced/complications/*diagnosis/*pathology
MH  - Prospective Studies
EDAT- 2009/01/28 09:00
MHDA- 2009/11/17 06:00
CRDT- 2009/01/28 09:00
PHST- 2009/01/28 09:00 [entrez]
PHST- 2009/01/28 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
AID - 10.4103/0378-6323.45105 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2008 Nov-Dec;74(6):619-21. doi: 
      10.4103/0378-6323.45105.