PMID- 19174039
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20201209
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 171
IP  - 4
DP  - 2009 Jan 19
TI  - [Bleeding peptic ulcer. Prevalence of Helicobacter pylori and use of nonsteroidal 
      anti-inflammatory drugs/acetylsalicylic acid].
PG  - 235-9
AB  - INTRODUCTION: Helicobacter pylori (HP) infection and use of nonsteroidal 
      anti-inflammatory drugs (NSAIDs)/acetyl salicylic acid (ASA) are risk factors for 
      bleeding peptic ulcer. HP eradication reduces the risk of rebleeding. 
      Antibiotics, proton pump inhibitors (PPI) and presence of blood in the stomach 
      can affect the HP test. The objectives of this study were to determine the HP 
      prevalence and NSAID/ASA use in patients with bleeding ulcer in a low-prevalence 
      HP area, to determine the proportion of idiopathic ulcers and to estimate the 
      proportion of initially false negative HP tests. In addition, the objective was 
      to describe changes in the characteristics of the patients who were admitted with 
      ulcer bleeding during the last two decades. MATERIAL AND METHODS: Retrospective 
      review of the records of patients who were admitted with a bleeding ulcer in 2003 
      to 2006 at The Department of Medical Gastroenterology S, Odense University 
      Hospital. Patients with initially negative or missing HP tests were offered a 
      urea breath test. This population was compared with prospective registrations for 
      the periods 1990-1992 and 2000. RESULTS: A total of 264 patients were admitted in 
      2003-2006. The mean age was 72 years. The HP-prevalence was 34%, and 81% had used 
      NSAID/ASA, as compared with 55% in 1990-1992. The proportion of idiopathic peptic 
      ulcer disease was 6.6%. At admission, 19% and 17% of the patients were in 
      treatment with PPI and antibiotics, respectively. Thirteen percent of the 
      initially HP-negative patients were later found to be HP-positive. CONCLUSION: 
      Compared to previous studies, we found a lower HP prevalence (34%) and a higher 
      proportion of NSAID/ASA usage (81%) in 2003-2006. As we found 13% false negative 
      HP-tests when factors that may affect the HP test were present, we advise that a 
      retest be made where these factors are present and the initial HP test is 
      negative.
FAU - Vestergard, Anders
AU  - Vestergard A
AD  - Medicinsk Gastroenterologisk Afdeling S, Odense Universitetshospital, DK-5000 
      Odense C. jane.hansen@dadlnet.dk
FAU - Bredahl, Kim
AU  - Bredahl K
FAU - de Muckadell, Ove B Schaffalitzky
AU  - de Muckadell OB
FAU - Pedersen, Ole Birger
AU  - Pedersen OB
FAU - Hansen, Jane Moller
AU  - Hansen JM
LA  - dan
PT  - Comparative Study
PT  - Journal Article
TT  - Blodende peptisk ulcus. Helicobacter pylori -praevalens og forbrug af 
      non-steroide antiinflammatoriske stoffer/acetylsalicylsyre.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*adverse effects
MH  - Aspirin/administration & dosage/*adverse effects
MH  - Duodenal Ulcer/chemically induced/etiology/microbiology
MH  - Female
MH  - Helicobacter Infections/*complications/diagnosis/drug therapy
MH  - *Helicobacter pylori/isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer Hemorrhage/chemically induced/*etiology/microbiology
MH  - Retrospective Studies
MH  - Stomach Ulcer/chemically induced/etiology/microbiology
EDAT- 2009/01/29 09:00
MHDA- 2009/02/05 09:00
CRDT- 2009/01/29 09:00
PHST- 2009/01/29 09:00 [entrez]
PHST- 2009/01/29 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
AID - VP02080097 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2009 Jan 19;171(4):235-9.