PMID- 19174182
OWN - NLM
STAT- MEDLINE
DCOM- 20090617
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 159
IP  - 2
DP  - 2009 Mar 17
TI  - Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal 
      firing of the midbrain raphe nuclei 5-HT neurons and a decrease of their response 
      to 5-HT(1A) receptor stimulation in the rat.
PG  - 850-61
LID - 10.1016/j.neuroscience.2008.12.051 [doi]
AB  - Several studies have shown that the 5-hydroxytryptamine (serotonin, 5-HT) system 
      is severely affected after degeneration of nigrostriatal dopaminergic neurons. In 
      the present study, we examined the changes in the firing rate and firing pattern 
      of the dorsal and median raphe nuclei (DRN and MRN) 5-HT neurons, and the effect 
      of the selective 5-HT(1A) receptor agonist 
      (R)-(+)-8-hydroxy-2-(dipropylamino)tetralin hydrobromide (8-OH-DPAT) and 
      antagonist (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridylcyclohexane 
      carboxamide maleate salt (WAY-100635) on the neuronal firing in rats with 
      6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta by using 
      extracellular recording. The unilateral lesion of the nigrostriatal pathway 
      significantly increased the mean firing rate of DRN and MRN 5-HT neurons compared 
      with normal rats, and the firing pattern of these neurons also changed 
      significantly towards a more bursty one. The lower dose of 8-OH-DPAT, 4 microg/kg 
      (cumulative doses, i.v.), completely inhibited the firing activity of all DRN and 
      MRN 5-HT neurons examined in normal and sham rats. In contrast to normal and sham 
      rats, only the higher doses of 8-OH-DPAT, 128 and 64 microg/kg, completely 
      inhibited the firing rate of DRN and MRN 5-HT neurons in 6-OHDA-lesioned rats, 
      respectively. Furthermore, the local application of 8-OH-DPAT, 1.5 microg, in the 
      DRN completely inhibited the firing rate of 5-HT neurons in normal and sham rats, 
      while having no effect on firing rate in the lesioned rats. Altogether, these 
      results indicate that lesion of the nigrostriatal pathway leads to hyperactivity 
      of DRN and MRN 5-HT neurons, suggesting the implication of the DRN and MRN in the 
      pathophysiology of Parkinson's disease, and the decreased response of these 5-HT 
      neurons to 5-HT(1A) receptor stimulation, reflecting 5-HT(1A) receptor 
      dysfunction in 6-OHDA-lesioned rats.
FAU - Wang, S
AU  - Wang S
AD  - Department of Physiology and Pathophysiology, School of Medicine, Xi'an Jiaotong 
      University, Xi'an 710061, Shaanxi, China.
FAU - Zhang, Q J
AU  - Zhang QJ
FAU - Liu, J
AU  - Liu J
FAU - Wu, Z H
AU  - Wu ZH
FAU - Wang, T
AU  - Wang T
FAU - Gui, Z H
AU  - Gui ZH
FAU - Chen, L
AU  - Chen L
FAU - Wang, Y
AU  - Wang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090103
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Action Potentials/drug effects/*physiology
MH  - Analysis of Variance
MH  - Animals
MH  - Corpus Striatum/physiology
MH  - Dose-Response Relationship, Drug
MH  - Functional Laterality/physiology
MH  - Male
MH  - Neural Inhibition/drug effects
MH  - Neural Pathways/drug effects/*injuries/physiology
MH  - Neurons/drug effects/*physiology
MH  - Piperazines/pharmacology
MH  - Pyridines/pharmacology
MH  - Raphe Nuclei/*cytology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/*physiology
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Statistics, Nonparametric
MH  - Substantia Nigra/physiology
EDAT- 2009/01/29 09:00
MHDA- 2009/06/18 09:00
CRDT- 2009/01/29 09:00
PHST- 2008/08/20 00:00 [received]
PHST- 2008/12/28 00:00 [revised]
PHST- 2008/12/30 00:00 [accepted]
PHST- 2009/01/29 09:00 [entrez]
PHST- 2009/01/29 09:00 [pubmed]
PHST- 2009/06/18 09:00 [medline]
AID - S0306-4522(08)01871-X [pii]
AID - 10.1016/j.neuroscience.2008.12.051 [doi]
PST - ppublish
SO  - Neuroscience. 2009 Mar 17;159(2):850-61. doi: 10.1016/j.neuroscience.2008.12.051. 
      Epub 2009 Jan 3.