PMID- 19174310
OWN - NLM
STAT- MEDLINE
DCOM- 20090507
LR  - 20090223
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 207
IP  - 1-2
DP  - 2009 Feb 15
TI  - Administration of bone marrow stromal cells ameliorates experimental autoimmune 
      myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets 
      through the secretion of TGF-beta.
PG  - 83-91
LID - 10.1016/j.jneuroim.2008.12.005 [doi]
AB  - Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against 
      human autoimmune diseases. Intravenous administration of syngenic BMSCs to 
      EAMG-model rats effectively ameliorated the disease, partially through a 
      TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG 
      rats was inhibited by BMSCs at proper cocultured ratios. And the imbalance of 
      Th1, Th2, Th17 and Treg cell subsets accompanied with the development of EAMG was 
      corrected by the administration of BMSCs. These results provide further insights 
      into the pathogenesis of MG, EAMG, and other immune-mediated diseases, and 
      support a potential role for BMSCs in their treatment.
FAU - Kong, Qing-Fei
AU  - Kong QF
AD  - Department of Neurobiology, Harbin Medical University, Heilongjiang Provincial 
      Key Laboratory of Neurobiology, 157 Bao Jian Road, Harbin 150081, China.
FAU - Sun, Bo
AU  - Sun B
FAU - Bai, Sha-Sha
AU  - Bai SS
FAU - Zhai, Dong-Xu
AU  - Zhai DX
FAU - Wang, Guang-You
AU  - Wang GY
FAU - Liu, Yu-Mei
AU  - Liu YM
FAU - Zhang, Shu-Juan
AU  - Zhang SJ
FAU - Li, Rui
AU  - Li R
FAU - Zhao, Wei
AU  - Zhao W
FAU - Sun, Yan-Yan
AU  - Sun YY
FAU - Li, Na
AU  - Li N
FAU - Wang, Qi
AU  - Wang Q
FAU - Peng, Hai-Sheng
AU  - Peng HS
FAU - Jin, Lian-Hong
AU  - Jin LH
FAU - Li, Hu-Lun
AU  - Li HL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090126
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulins)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology/metabolism
MH  - Body Weight
MH  - Bone Marrow Transplantation/*methods
MH  - Cell Proliferation
MH  - Coculture Techniques/methods
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulins/metabolism
MH  - Myasthenia Gravis, Autoimmune, Experimental/immunology/*surgery
MH  - Peptides/immunology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Receptors, Cholinergic/immunology
MH  - Stromal Cells/immunology/*transplantation
MH  - T-Lymphocytes, Helper-Inducer/classification/immunology/*metabolism
MH  - T-Lymphocytes, Regulatory/immunology/*metabolism
MH  - Time Factors
MH  - Transforming Growth Factor beta/immunology/*metabolism
EDAT- 2009/01/29 09:00
MHDA- 2009/05/08 09:00
CRDT- 2009/01/29 09:00
PHST- 2008/09/22 00:00 [received]
PHST- 2008/12/03 00:00 [revised]
PHST- 2008/12/16 00:00 [accepted]
PHST- 2009/01/29 09:00 [entrez]
PHST- 2009/01/29 09:00 [pubmed]
PHST- 2009/05/08 09:00 [medline]
AID - S0165-5728(08)00495-5 [pii]
AID - 10.1016/j.jneuroim.2008.12.005 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2009 Feb 15;207(1-2):83-91. doi: 10.1016/j.jneuroim.2008.12.005. 
      Epub 2009 Jan 26.