PMID- 19175563
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20220223
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 22
IP  - 5
DP  - 2009 May
TI  - Is it possible to predict the early post-transplant allograft function using 
      20-HETE measurements? A preliminary report.
PG  - 546-53
LID - 10.1111/j.1432-2277.2008.00829.x [doi]
AB  - 20-HydroxyEicosaTetraEnoic (20-HETE) acid is an arachidonic acid metabolite that 
      is generated via cytochrome P450 enzymes, and according to the findings from 
      recent studies, may be involved in the pathogenesis of ischemia-reperfusion 
      injury. The aim of this study was to: examine the dynamics of 20-HETE changes 
      during the first 5 min of allograft reperfusion, and analyze whether the observed 
      changes are associated with post-transplant graft function. Sixty-nine renal 
      transplant recipients were divided, according to their outcome, into early, slow 
      and delayed graft function (EGF, SGF, DGF) group. Blood samples were collected 
      directly before and during the first 5 min of allograft reperfusion. 20-HETE 
      concentrations were measured using ELISA. The results demonstrated significant 
      differences in the concentrations and in the dynamics of 20-HETE changes between 
      patients with immediate graft function, and individuals with allograft activation 
      problems. The sensitivity, specificity, positive and negative predictive value of 
      20-HETEDelta(5-0) parameter in discriminating EGF and SGF from DGF were 69%, 54%, 
      74% and 48% respectively. Therefore, our results demonstrated that the dynamics 
      of 20-HETE changes, which occurs during early phase of allograft reperfusion, is 
      associated with early post-transplant graft function and also highlighted 20-HETE 
      as a novel clinical marker of post-transplant allograft function.
FAU - Dolegowska, Barbara
AU  - Dolegowska B
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 
      Szczecin, Poland.
FAU - Blogowski, Wojciech
AU  - Blogowski W
FAU - Domanski, Leszek
AU  - Domanski L
LA  - eng
PT  - Journal Article
DEP - 20090114
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Hydroxyeicosatetraenoic Acids)
RN  - 79551-86-3 (20-hydroxy-5,8,11,14-eicosatetraenoic acid)
SB  - IM
MH  - Adult
MH  - Delayed Graft Function/*immunology
MH  - Female
MH  - Humans
MH  - Hydroxyeicosatetraenoic Acids/*blood
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Regression Analysis
MH  - Transplantation, Homologous/*immunology
EDAT- 2009/01/30 09:00
MHDA- 2009/06/09 09:00
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
AID - TRI829 [pii]
AID - 10.1111/j.1432-2277.2008.00829.x [doi]
PST - ppublish
SO  - Transpl Int. 2009 May;22(5):546-53. doi: 10.1111/j.1432-2277.2008.00829.x. Epub 
      2009 Jan 14.