PMID- 19175595
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20151119
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 3
DP  - 2009 Mar
TI  - A quantitative genetic analysis of intermediate asthma phenotypes.
PG  - 427-30
LID - 10.1111/j.1398-9995.2008.01850.x [doi]
AB  - AIM: To study the relative contribution of genetic and environmental factors to 
      the correlation between exhaled nitric oxide (FeNO), airway responsiveness, 
      airway obstruction, and serum total immunoglobulin E (IgE). METHODS: Within a 
      sampling frame of 21,162 twin subjects, 20-49 years of age, from the Danish Twin 
      Registry, a total of 575 subjects (256 intact pairs and 63 single twins) who 
      either themselves and/or their co-twins reported a history of asthma at a 
      nationwide questionnaire survey, were clinically examined. Traits were measured 
      using standard techniques. Latent factor models were fitted to the observed data 
      using maximum likelihood methods. RESULTS: Additive genetic factors explained 67% 
      of the variation in FeNO, 43% in airway responsiveness, 22% in airway 
      obstruction, and 81% in serum total IgE. In general, traits had genetically and 
      environmentally distinct variance structures. The most substantial genetic 
      similarity was observed between FeNO and serum total IgE, genetic correlation 
      (rhoA) = 0.37, whereas the strongest environmental resemblance was observed 
      between airway responsiveness and airway obstruction, specific environmental 
      correlation (rhoE) = -0.46, and between FeNO and airway responsiveness, rhoE = 
      0.34. CONCLUSIONS: Asthma is a complex disease characterized by a set of 
      etiologically heterogeneous biomarkers, which likely constitute diverse targets 
      of intervention.
FAU - Thomsen, S F
AU  - Thomsen SF
AD  - Department of Respiratory Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
FAU - Ferreira, M A R
AU  - Ferreira MA
FAU - Kyvik, K O
AU  - Kyvik KO
FAU - Fenger, M
AU  - Fenger M
FAU - Backer, V
AU  - Backer V
LA  - eng
PT  - Journal Article
PT  - Twin Study
DEP - 20090127
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/blood/*genetics/*physiopathology
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Phenotype
MH  - Respiratory Function Tests
MH  - Surveys and Questionnaires
EDAT- 2009/01/30 09:00
MHDA- 2009/05/27 09:00
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
AID - ALL1850 [pii]
AID - 10.1111/j.1398-9995.2008.01850.x [doi]
PST - ppublish
SO  - Allergy. 2009 Mar;64(3):427-30. doi: 10.1111/j.1398-9995.2008.01850.x. Epub 2009 
      Jan 27.