PMID- 19175774
OWN - NLM
STAT- MEDLINE
DCOM- 20090430
LR  - 20090217
IS  - 1468-2982 (Electronic)
IS  - 0333-1024 (Linking)
VI  - 29
IP  - 3
DP  - 2009 Mar
TI  - Cerebrospinal fluid cytokine levels in migraine, tension-type headache and 
      cervicogenic headache.
PG  - 365-72
LID - 10.1111/j.1468-2982.2008.01727.x [doi]
AB  - Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients 
      [infrequent episodic tension-type headache (TTH) and migraine with or without 
      aura, all during attack, and cervicogenic headache] and compared with levels in 
      pain-free individuals. Both proinflammatory [interleukin (IL)-1beta, tumour 
      necrosis factor-alpha and monocyte chemoattractant protein-1 (MCP-1)] and 
      anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and 
      transforming growth factor-beta1 (TGF-beta1)] were included. There were 
      significant group differences in IL-1ra, TGF-beta1 and MCP-1 in episodic TTH and 
      migraine compared with controls, and a significant difference in MCP-1 between 
      cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with 
      IL-1ra, IL-10 and TGF-beta1 in episodic TTH, and MCP-1 with IL-10 in migraine 
      with aura. Cytokine increases were modest compared with those often accompanying 
      serious neurological conditions, and may represent a mild response to pain. We 
      believe this to be the first comparative study of CSF cytokine levels in 
      connection with headache.
FAU - Bo, S H
AU  - Bo SH
AD  - Department of Neurology, Akershus University Hospital, Lorenskog, Norway.
FAU - Davidsen, E M
AU  - Davidsen EM
FAU - Gulbrandsen, P
AU  - Gulbrandsen P
FAU - Dietrichs, E
AU  - Dietrichs E
FAU - Bovim, G
AU  - Bovim G
FAU - Stovner, L J
AU  - Stovner LJ
FAU - White, L R
AU  - White LR
LA  - eng
PT  - Journal Article
DEP - 20081022
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/cerebrospinal fluid
MH  - Cytokines/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Interleukin-10/cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/*cerebrospinal fluid
MH  - Post-Traumatic Headache/*cerebrospinal fluid
MH  - Receptors, Interleukin-1/analysis
MH  - Tension-Type Headache/*cerebrospinal fluid
MH  - Transforming Growth Factor beta1/cerebrospinal fluid
EDAT- 2009/01/30 09:00
MHDA- 2009/05/01 09:00
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/05/01 09:00 [medline]
AID - CHA1727 [pii]
AID - 10.1111/j.1468-2982.2008.01727.x [doi]
PST - ppublish
SO  - Cephalalgia. 2009 Mar;29(3):365-72. doi: 10.1111/j.1468-2982.2008.01727.x. Epub 
      2008 Oct 22.