PMID- 19175852
OWN - NLM
STAT- MEDLINE
DCOM- 20090610
LR  - 20090305
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 20
IP  - 3
DP  - 2009 Mar
TI  - Relationship of reverse anatomical remodeling and ventricular arrhythmias after 
      cardiac resynchronization.
PG  - 293-8
LID - 10.1111/j.1540-8167.2008.01317.x [doi]
AB  - INTRODUCTION: Cardiac resynchronization (CRT) affects reverse anatomical 
      remodeling in patients with heart failure. CRT has also been associated with 
      fewer ventricular arrhythmias and reduced sudden death in some clinical trials, 
      but the predictors and mechanism of the antiarrhythmic actions of CRT have not 
      been well defined. The purpose of this study is to investigate the relationship 
      of reverse anatomical remodeling to ventricular arrhythmias in CRT patients. 
      METHODS AND RESULTS: A retrospective analysis was performed of the InSync III 
      Marquis study, a prospective, randomized, multicenter CRT trial. 
      Echocardiographic data from 198 patients were obtained at baseline and after 6 
      months of CRT, and anatomical responders were defined as a reduction in left 
      ventricular end systolic volume (LVESV) of >or=15%. Anatomical responders (n = 
      71, 36%) demonstrated 29% fewer single premature ventricular contractions beats 
      (PVCs) (P = 0.0001), 48% fewer PVC runs (p = 0.0096), and fewer treated episodes 
      of ventricular tachycardia or fibrillation (VT/VF) (P = 0.050) than 
      nonresponders. Multiple regression analysis demonstrated that responder status 
      significantly predicted single PVCs and PVC runs. Gender was the most important 
      predictor of treated VT/VF with females having no episodes over 6 months of 
      follow-up. CONCLUSIONS: Anatomic responders to CRT demonstrate significantly 
      fewer single PVCs and runs of PVCs. The implication of these observations is that 
      anatomic remodeling is linked to electrical remodeling.
FAU - Markowitz, Steven M
AU  - Markowitz SM
AD  - Division of Cardiology, Department of Medicine, Cornell University Medical 
      Center, New York, New York 10021, USA. smarkow@med.cornell.edu
FAU - Lewen, Jason M
AU  - Lewen JM
FAU - Wiggenhorn, Christopher J
AU  - Wiggenhorn CJ
FAU - Abraham, William T
AU  - Abraham WT
FAU - Stein, Kenneth M
AU  - Stein KM
FAU - Iwai, Sei
AU  - Iwai S
FAU - Lerman, Bruce B
AU  - Lerman BB
LA  - eng
GR  - R01 HL56139/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081030
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Aged
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Statistics as Topic
MH  - Treatment Outcome
MH  - United States
MH  - Ventricular Dysfunction, Left/diagnosis/*etiology/*prevention & control
MH  - Ventricular Fibrillation/*complications/diagnosis/*prevention & control
MH  - *Ventricular Remodeling
EDAT- 2009/01/30 09:00
MHDA- 2009/06/11 09:00
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/06/11 09:00 [medline]
AID - JCE1317 [pii]
AID - 10.1111/j.1540-8167.2008.01317.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2009 Mar;20(3):293-8. doi: 
      10.1111/j.1540-8167.2008.01317.x. Epub 2008 Oct 30.