PMID- 19176316
OWN - NLM
STAT- MEDLINE
DCOM- 20090507
LR  - 20220419
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 15
DP  - 2009 Apr 9
TI  - Dendritic cell homeostasis.
PG  - 3418-27
LID - 10.1182/blood-2008-12-180646 [doi]
AB  - Dendritic cells (DCs) are a heterogeneous fraction of rare hematopoietic cells 
      that coevolved with the formation of the adaptive immune system. DCs efficiently 
      process and present antigen, move from sites of antigen uptake to sites of 
      cellular interactions, and are critical in the initiation of immune responses as 
      well as in the maintenance of self-tolerance. DCs are distributed throughout the 
      body and are enriched in lymphoid organs and environmental contact sites. 
      Steady-state DC half-lives account for days to up to a few weeks, and they need 
      to be replaced via proliferating hematopoietic progenitors, monocytes, or tissue 
      resident cells. In this review, we integrate recent knowledge on DC progenitors, 
      cytokines, and transcription factor usage to an emerging concept of in vivo DC 
      homeostasis in steady-state and inflammatory conditions. We furthermore highlight 
      how knowledge of these maintenance mechanisms might impact on understanding of DC 
      malignancies as well as posttransplant immune reactions and their respective 
      therapies.
FAU - Merad, Miriam
AU  - Merad M
AD  - Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, 
      NY 10029, USA. miriam.merad@mssm.edu
FAU - Manz, Markus G
AU  - Manz MG
LA  - eng
GR  - R01AI0086899/AI/NIAID NIH HHS/United States
GR  - R01CA1121100/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090127
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - Dendritic Cells/*cytology/*immunology
MH  - Homeostasis/*immunology
MH  - Humans
MH  - Transplantation Immunology/*immunology
PMC - PMC2668851
EDAT- 2009/01/30 09:00
MHDA- 2009/05/08 09:00
PMCR- 2009/04/09
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/05/08 09:00 [medline]
PHST- 2009/04/09 00:00 [pmc-release]
AID - S0006-4971(20)39338-1 [pii]
AID - 2008/180646 [pii]
AID - 10.1182/blood-2008-12-180646 [doi]
PST - ppublish
SO  - Blood. 2009 Apr 9;113(15):3418-27. doi: 10.1182/blood-2008-12-180646. Epub 2009 
      Jan 27.