PMID- 19176608
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20131121
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 101
IP  - 4
DP  - 2009 Apr
TI  - Adaptation to visuomotor rotation and force field perturbation is correlated to 
      different brain areas in patients with cerebellar degeneration.
PG  - 1961-71
LID - 10.1152/jn.91069.2008 [doi]
AB  - Although it is widely agreed that the cerebellum is necessary for learning and 
      consolidation of new motor tasks, it is not known whether adaptation to kinematic 
      and dynamic errors is processed by the same cerebellar areas or whether different 
      parts play a decisive role. We investigated arm movements in a visuomotor (VM) 
      rotation and a force field (FF) perturbation task in 14 participants with 
      cerebellar degeneration and 14 age- and gender-matched controls. Magnetic 
      resonance images were used to calculate the volume of cerebellar areas (medial, 
      intermediate, and lateral zones of the anterior and posterior lobes) and to 
      identify cerebellar structure important for the two tasks. Corroborating previous 
      studies, cerebellar participants showed deficits in adaptation to both tasks 
      compared with controls (P < 0.001). However, it was not possible to draw 
      conclusions from the performance in one task on the performance in the other task 
      because an individual participant could show severe impairment in one task and 
      perform relatively well in the other (rho = 0.1; P = 0.73). We found that atrophy 
      of distinct cerebellar areas correlated with impairment in different tasks. 
      Whereas atrophy of the intermediate and lateral zone of the anterior lobe 
      correlated with impairment in the FF task (rho = 0.72, 0.70; P = 0.003, 0.005, 
      respectively), atrophy of the intermediate zone of the posterior lobe correlated 
      with adaptation deficits in the VM task (rho = 0.64; P = 0.015). Our results 
      suggest that adaptation to the different tasks is processed independently and 
      relies on different cerebellar structures.
FAU - Rabe, K
AU  - Rabe K
AD  - Department of Biomedical Engineering, Ben Gurion University of the Negev, Be'er 
      Sheva 84105, Israel.
FAU - Livne, O
AU  - Livne O
FAU - Gizewski, E R
AU  - Gizewski ER
FAU - Aurich, V
AU  - Aurich V
FAU - Beck, A
AU  - Beck A
FAU - Timmann, D
AU  - Timmann D
FAU - Donchin, O
AU  - Donchin O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090128
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - Brain/pathology/*physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Functional Laterality
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Motor Skills Disorders/*etiology
MH  - Movement/physiology
MH  - Psychomotor Performance/physiology
MH  - *Rotation
MH  - Spinocerebellar Degenerations/*pathology/physiopathology
MH  - Task Performance and Analysis
MH  - Visual Perception/*physiology
EDAT- 2009/01/30 09:00
MHDA- 2009/05/27 09:00
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
AID - 91069.2008 [pii]
AID - 10.1152/jn.91069.2008 [doi]
PST - ppublish
SO  - J Neurophysiol. 2009 Apr;101(4):1961-71. doi: 10.1152/jn.91069.2008. Epub 2009 
      Jan 28.