PMID- 19177066
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20211020
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 34
IP  - 7
DP  - 2009 Jun
TI  - Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral 
      effects of chronic antidepressant treatments.
PG  - 1764-73
LID - 10.1038/npp.2008.234 [doi]
AB  - Chronic administration of antidepressant drugs produce changes in neuroplasticity 
      and behavior in rodents, effects that may be associated with the slow emergence 
      of clinical therapeutic effects. Owing to the uncertainty over the effects of 
      chronic antidepressant treatments in mice, these experiments compared the 
      regulation of neurogenesis, neurotrophin levels, and behavior produced by chronic 
      antidepressant treatments between two inbred mouse strains, MRL/MpJ and C57BL/6J. 
      The MRL/MpJ strain is associated with enhanced wound healing and tissue 
      regeneration, whereas C57BL/6J mice are used commonly for behavioral studies. 
      Proliferation and survival of hippocampal progenitor cells were measured using 
      flow cytometry, a new platform that rapidly quantifies the incorporation of 
      5-bromo-2-deoxyuridine (BrdU). Hippocampal cell proliferation was increased 
      significantly after chronic administration of fluoxetine (FLX: 5, 10 mg/kg, 
      intraperitoneal (i.p.), b.i.d.) or desipramine (DMI: 5, 10 mg/kg, i.p., b.i.d.) 
      for 21 days in MRL/MpJ mice, but not in C57BL/6J mice. Hippocampal progenitor 
      cells born prior to chronic antidepressant treatments were not affected in either 
      mouse strain. Protein levels of brain-derived neurotrophic factor (BDNF) in 
      MRL/MpJ mice were elevated significantly in the frontal cortex, hippocampus, and 
      amygdala after chronic FLX treatment, but increased only in the frontal cortex by 
      chronic DMI. In contrast, BDNF levels in C57BL/6J mice were decreased in the 
      hippocampus and increased in the amygdala after chronic FLX, and were decreased 
      in the brain stem after chronic DMI. Novelty-induced hypophagia (NIH) was used to 
      examine a behavioral effect produced by chronic antidepressant treatment. MRL/MpJ 
      mice, chronically administered FLX or DMI, had significantly shorter latencies to 
      consume food when exposed to a novel environment than untreated mice, whereas 
      there were no effects on the behavior of C57BL/6J mice. In conclusion, robust 
      effects of chronic antidepressant treatments on hippocampal cell proliferation 
      and BDNF levels paralleled the ability of these drugs to produce changes in NIH 
      behavior in MRL/MpJ, while none of these effects were produced in C57BL/6J mice. 
      The greater responsiveness of MRL/MpJ mice may be important for drug discovery, 
      for genetic studies, and for understanding the neural mechanisms underlying the 
      physiological and behavioral effects of chronic antidepressant treatments.
FAU - Balu, Darrick T
AU  - Balu DT
AD  - Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, 
      USA.
FAU - Hodes, Georgia E
AU  - Hodes GE
FAU - Anderson, Brian T
AU  - Anderson BT
FAU - Lucki, Irwin
AU  - Lucki I
LA  - eng
GR  - U01 MH072832-02/MH/NIMH NIH HHS/United States
GR  - U01 MH072832-03/MH/NIMH NIH HHS/United States
GR  - MH72832/MH/NIMH NIH HHS/United States
GR  - U01 MH072832/MH/NIMH NIH HHS/United States
GR  - T32 MH014654/MH/NIMH NIH HHS/United States
GR  - T32 MH014654-31/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20090128
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 01K63SUP8D (Fluoxetine)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain/cytology/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Proliferation/drug effects
MH  - Desipramine/*pharmacology
MH  - Eating/drug effects
MH  - Exploratory Behavior/drug effects
MH  - Flow Cytometry
MH  - Fluoxetine/*pharmacology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Neurogenesis/*drug effects
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/drug effects/metabolism
MH  - Reaction Time/drug effects
PMC - PMC2680932
MID - NIHMS83852
EDAT- 2009/01/30 09:00
MHDA- 2009/08/04 09:00
PMCR- 2009/12/01
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
PHST- 2009/12/01 00:00 [pmc-release]
AID - npp2008234 [pii]
AID - 10.1038/npp.2008.234 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2009 Jun;34(7):1764-73. doi: 10.1038/npp.2008.234. Epub 
      2009 Jan 28.