PMID- 19177190
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20090709
LR  - 20220321
IS  - 0912-0009 (Print)
IS  - 1880-5086 (Electronic)
IS  - 0912-0009 (Linking)
VI  - 44
IP  - 1
DP  - 2009 Jan
TI  - In Vitro Effects of the Reduced Form of Coenzyme Q(10) on Secretion Levels of 
      TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line 
      THP-1.
PG  - 62-6
LID - 10.3164/jcbn.08-182 [doi]
AB  - Ubiquinol-10 (QH(2)), the reduced form of Coenzyme Q(10) (CoQ(10)) serves as a 
      potent antioxidant of lipid membranes. Because many antioxidants reveal potent 
      anti-inflammatory effects, the influence of QH(2) on lipopolysaccharide 
      (LPS)-induced pro-inflammatory cytokines and chemokines were determined in the 
      human monocytic cell line THP-1. Stimulation of cells with LPS resulted in a 
      distinct release of Tumour necrosis factor-alpha (TNF-alpha), Macrophage 
      inflammatory protein-1 alpha (MIP-1alpha), Regulated upon activation, normal T 
      cell expressed and secreted (RANTES) and Monocyte chemotattractant protein-1 
      (MCP-1). The LPS-induced responses were significantly decreased by pre-incubation 
      of cells with QH(2) to 60.27 +/- 9.3% (p = 0.0009), 48.13 +/- 6.93% (p = 0.0007) 
      and 74.36 +/- 7.25% (p = 0.008) for TNF-alpha, MIP-1alpha and RANTES, 
      respectively. In conclusion, our results indicate anti-inflammatory effects of 
      the reduced form of CoQ(10) on various proinflammatory cytokines and chemokines 
      in vitro.
FAU - Schmelzer, Constance
AU  - Schmelzer C
AD  - Institute of Human Nutrition and Food Science, Molecular Nutrition, 
      Christian-Albrechts-University of Kiel, Heinrich-Hecht-Platz 10, 24118 Kiel, 
      Germany.
FAU - Lorenz, Gerti
AU  - Lorenz G
FAU - Rimbach, Gerald
AU  - Rimbach G
FAU - Doring, Frank
AU  - Doring F
LA  - eng
PT  - Journal Article
DEP - 20081227
PL  - Japan
TA  - J Clin Biochem Nutr
JT  - Journal of clinical biochemistry and nutrition
JID - 8700907
PMC - PMC2613501
OTO - NOTNLM
OT  - coenzyme Q10
OT  - inflammation
OT  - monocytes
OT  - ubiquinol-10
EDAT- 2009/01/30 09:00
MHDA- 2009/01/30 09:01
PMCR- 2009/01/01
CRDT- 2009/01/30 09:00
PHST- 2007/05/26 00:00 [received]
PHST- 2008/07/25 00:00 [accepted]
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/01/30 09:01 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
AID - jcbn08-182 [pii]
AID - 10.3164/jcbn.08-182 [doi]
PST - ppublish
SO  - J Clin Biochem Nutr. 2009 Jan;44(1):62-6. doi: 10.3164/jcbn.08-182. Epub 2008 Dec 
      27.