PMID- 19177525
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20220311
IS  - 0004-3591 (Print)
IS  - 1529-0131 (Electronic)
IS  - 0004-3591 (Linking)
VI  - 61
IP  - 2
DP  - 2009 Feb 15
TI  - Health-related quality of life for patients with vasculitis and their spouses.
PG  - 259-65
LID - 10.1002/art.24235 [doi]
AB  - OBJECTIVE: Chronic disease affects both patients and spouses, yet the effect of 
      vasculitis on the spouses of patients has not been systematically examined. We 
      addressed this research gap by describing 8 dimensions of health-related quality 
      of life (HRQOL) for antineutrophil cytoplasmic antibody-associated vasculitis 
      (AAV) patients and their spouses and compared patients and spouses with norms for 
      the general US population. We also determined whether the impact of AAV on HRQOL 
      differs by sex for patients or their spouses. METHODS: Ninety-seven patients with 
      AAV and their spouses completed a mailed questionnaire that included demographic 
      information and a measure of HRQOL (Medical Outcomes Study Short Form 36.) Using 
      the RAND method, we calculated 8 HRQOL dimensions: general health, physical 
      functioning, emotional role limitations, physical role limitations, social 
      functioning, mental health, bodily pain, and energy/vitality. Using norm-based 
      scores, we compared the HRQOL of patients and spouses with the general US 
      population. We then used multivariate analysis of covariance (MANCOVA) test for 
      sex differences in HRQOL for patients and spouses. RESULTS: Patients with AAV 
      scored lower than the US norm on all HRQOL subscales with the exception of bodily 
      pain. In contrast, spouses scored similarly to national norms. When age, 
      education, race, illness duration, and disease severity were controlled, there 
      were no significant sex differences in HRQOL for patients or spouses. CONCLUSION: 
      AAV negatively impacts HRQOL for patients; whereas, spouses do not appear to be 
      as negatively impacted. Long-term marriages may attenuate the effect of sex on 
      HRQOL. Quality of life should be assessed throughout the disease course for both 
      patients and spouses.
FAU - Carpenter, Delesha M
AU  - Carpenter DM
AD  - University of North Carolina, Chapel Hill, NC 27599, USA. dlmiller@email.unc.edu
FAU - Thorpe, Carolyn T
AU  - Thorpe CT
FAU - Lewis, Megan
AU  - Lewis M
FAU - Devellis, Robert F
AU  - Devellis RF
FAU - Hogan, Susan L
AU  - Hogan SL
LA  - eng
GR  - P60-AR49465-05/AR/NIAMS NIH HHS/United States
GR  - P60 AR049465/AR/NIAMS NIH HHS/United States
GR  - T32 DK007750/DK/NIDDK NIH HHS/United States
GR  - T32 DK007750-09/DK/NIDDK NIH HHS/United States
GR  - P01 DK058335/DK/NIDDK NIH HHS/United States
GR  - P01 DK058335-099001/DK/NIDDK NIH HHS/United States
GR  - P01 DK058335-109001/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Churg-Strauss Syndrome/psychology
MH  - Cohort Studies
MH  - Female
MH  - *Granulomatosis with Polyangiitis/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Sex Factors
MH  - *Spouses/psychology
PMC - PMC2839505
MID - NIHMS181902
EDAT- 2009/01/30 09:00
MHDA- 2009/04/15 09:00
PMCR- 2010/03/16
CRDT- 2009/01/30 09:00
PHST- 2009/01/30 09:00 [entrez]
PHST- 2009/01/30 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2010/03/16 00:00 [pmc-release]
AID - 10.1002/art.24235 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2009 Feb 15;61(2):259-65. doi: 10.1002/art.24235.