PMID- 19178612
OWN - NLM
STAT- MEDLINE
DCOM- 20090904
LR  - 20181201
IS  - 1610-0387 (Electronic)
IS  - 1610-0379 (Linking)
VI  - 7
IP  - 5
DP  - 2009 May
TI  - Perforating folliculitis, angioedema, hand-foot syndrome--multiple cutaneous side 
      effects in a patient treated with sorafenib.
PG  - 449-52
LID - 10.1111/j.1610-0387.2009.07017.x [doi]
AB  - A patient with clear cell renal cell carcinoma was treated with sorafenib, a 
      multikinase inhibitor, which induced a variety of cutaneous side effects. In 
      addition to xerosis, he developed angioedema (AE), hand-foot syndrome (HFS) and 
      perforating folliculitis (PF). The latter three occurred in a dose-dependent 
      manner. AE was observed at the recommended daily dose of 800 mg. Dose reduction 
      to 400 mg prevented its recurrence. At this dose level, the patient exhibited 
      HFS, which cleared upon further reduction of the dose. While receiving 200 mg, 
      the patient developed PF. To the best of our knowledge, this is the first 
      description of a case of PF during treatment with sorafenib.
FAU - Wolber, Carola
AU  - Wolber C
AD  - Donauspital SMZ Ost, Department of Dermatology and Venereology, Vienna, Austria. 
      Carola.Wolber@wienkav.at
FAU - Udvardi, Astrid
AU  - Udvardi A
FAU - Tatzreiter, Georg
AU  - Tatzreiter G
FAU - Schneeberger, Achim
AU  - Schneeberger A
FAU - Volc-Platzer, Beatrix
AU  - Volc-Platzer B
LA  - eng
LA  - ger
PT  - Case Reports
PT  - Journal Article
DEP - 20090129
PL  - Germany
TA  - J Dtsch Dermatol Ges
JT  - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German 
      Society of Dermatology : JDDG
JID - 101164708
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzenesulfonates)
RN  - 0 (Phenylurea Compounds)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Pyridines)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 9ZOQ3TZI87 (Sorafenib)
SB  - IM
MH  - Aged
MH  - Angioedema/*chemically induced
MH  - Antineoplastic Agents/adverse effects
MH  - Benzenesulfonates/*adverse effects
MH  - Diagnosis, Differential
MH  - Drug Eruptions/diagnosis/*etiology
MH  - Folliculitis/*chemically induced/diagnosis
MH  - Foot Dermatoses/*chemically induced/diagnosis
MH  - Hand Dermatoses/*chemically induced/diagnosis
MH  - Humans
MH  - Male
MH  - Niacinamide/analogs & derivatives
MH  - Phenylurea Compounds
MH  - Protein Kinase Inhibitors/adverse effects
MH  - Pyridines/*adverse effects
MH  - Sorafenib
MH  - Syndrome
EDAT- 2009/01/31 09:00
MHDA- 2009/09/05 06:00
CRDT- 2009/01/31 09:00
PHST- 2009/01/31 09:00 [entrez]
PHST- 2009/01/31 09:00 [pubmed]
PHST- 2009/09/05 06:00 [medline]
AID - DDG07017 [pii]
AID - 10.1111/j.1610-0387.2009.07017.x [doi]
PST - ppublish
SO  - J Dtsch Dermatol Ges. 2009 May;7(5):449-52. doi: 
      10.1111/j.1610-0387.2009.07017.x. Epub 2009 Jan 29.