PMID- 19179739
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20111117
IS  - 0019-6061 (Print)
IS  - 0019-6061 (Linking)
VI  - 46
IP  - 4
DP  - 2009 Apr
TI  - Cord serum screening test and the newborns allergic status.
PG  - 295-9
AB  - OBJECTIVE: To evaluate the predictive value of a cord serum screen test and 
      possible subsequent development of allergic disease in infants. DESIGN: Cohort 
      study. SETTING: 100 pregnant women were randomly recruited for the study. 
      METHODS: The maternal serum and the cord serum of their matched newborn were 
      analyzed for total serum immunoglobulin E (IgE), gamma interferon (g IFN), house 
      dust mite- Dermatophagoides pteronyssinus allergen (Der p1) and Blomia tropicalis 
      allergen (Blo t5) using immunoassay methods. All infants were followed up for one 
      year. RESULTS: Infants who had allergic diseases in the one year follow-up (n=45) 
      had significantly (P < 0.001) elevated IgE, Der p1, Blo t5, and significantly low 
      g IFN levels in cord serum as compared to the same parameters of infants who did 
      not develop allergic disease in the one year follow-up (n=43). CONCLUSION: In 
      utero exposure to HDM allergens Der p1 and Blot5 is prevalent. We have 
      successfully established a cord serum screening test for predicting allergic 
      diseases in infancy with 93% specificity and sensitivity.
FAU - Shah, Shilpa
AU  - Shah S
AD  - Breach Candy Hospital Trust, 60A Bhulabhai Desai Road, Mumbai 400 026, India. 
      rescience_5@yahoo.co.in
FAU - Bapat, M
AU  - Bapat M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090101
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Antigens, Plant)
RN  - 0 (Arthropod Proteins)
RN  - 0 (allergen Blo t 5)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.- (Dermatophagoides pteronyssinus antigen p 1)
SB  - IM
MH  - Allergens/blood
MH  - Antigens, Dermatophagoides/blood
MH  - Antigens, Plant
MH  - Arthropod Proteins
MH  - Cysteine Endopeptidases
MH  - Female
MH  - Fetal Blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*blood/*diagnosis
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Interferon-gamma/blood
MH  - Male
MH  - Neonatal Screening/*methods
MH  - Predictive Value of Tests
MH  - Pregnancy
EDAT- 2009/01/31 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/01/31 09:00
PHST- 2007/03/27 00:00 [received]
PHST- 2008/07/21 00:00 [accepted]
PHST- 2009/01/31 09:00 [entrez]
PHST- 2009/01/31 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S001960610800187-1 [pii]
PST - ppublish
SO  - Indian Pediatr. 2009 Apr;46(4):295-9. Epub 2009 Jan 1.