PMID- 19179834
OWN - NLM
STAT- MEDLINE
DCOM- 20090330
LR  - 20211020
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 20
IP  - 6
DP  - 2008 Dec
TI  - Use of cereal fiber to facilitate adherence to a human caloric restriction 
      program.
PG  - 513-20
AB  - BACKGROUND AND AIMS: Caloric restriction (CR) attenuates biological aging in 
      animal models but there is little information on the feasibility and efficacy of 
      CR regimens in humans. We examined the effects of consuming an insoluble cereal 
      fiber supplement on ability to sustain CR over 1 year in healthy overweight 
      adults. METHODS: In 34 healthy overweight women and men (BMI 25-30 kg/m2, age 
      20-42 yr), a 30% CR regimen meeting national recommendations for dietary fiber 
      was provided for 24 weeks, and for an additional 24 weeks subjects were counseled 
      to prepare the same regimen at home. During 5-10 weeks of CR, subjects were 
      randomized to consume an extra 20 g/day of dietary fiber from a high fiber cereal 
      (+F) or to not consume additional fiber (-F). After this time, all subjects were 
      encouraged to consume the extra fiber. Outcomes included adherence to the 
      provided and self-prepared CR regimens (energy intake determined using doubly 
      labeled water), changes in body weight, and self-reported satisfaction with the 
      amount of consumed food. RESULTS: During 5-10 weeks of CR when all food was 
      provided, both +F and -F groups were highly adherent to the CR regimen and there 
      was no significant difference between groups in energy intake (p=0.51), weight 
      change (p=0.96), or satisfaction with amount of provided food (p=0.08). During 
      self-prepared CR from 25 to 48 weeks, mean adherence was lower than during the 
      food-provided phase and there was a significant association between fiber intake 
      and % CR (r=0.69, p<0.001), decreased BMI (r=- 0.38, p=0.04) and satisfaction 
      with the amount of consumed food (r=0.59, p=0.002). CONCLUSIONS: A high fiber 
      cereal intake may facilitate CR in humans self-selecting their own food; 
      longer-term intervention studies are needed to confirm these findings.
FAU - Gilhooly, Cheryl H
AU  - Gilhooly CH
AD  - Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 
      Boston, MA 02111, USA.
FAU - Das, Sai Krupa
AU  - Das SK
FAU - Golden, Julie K
AU  - Golden JK
FAU - McCrory, Megan A
AU  - McCrory MA
FAU - Rochon, James
AU  - Rochon J
FAU - DeLany, James P
AU  - DeLany JP
FAU - Freed, Alicia M
AU  - Freed AM
FAU - Fuss, Paul J
AU  - Fuss PJ
FAU - Dallal, Gerard E
AU  - Dallal GE
FAU - Saltzman, Edward
AU  - Saltzman E
FAU - Roberts, Susan B
AU  - Roberts SB
LA  - eng
GR  - U01 AG020480-05/AG/NIA NIH HHS/United States
GR  - U01 AG020480-02/AG/NIA NIH HHS/United States
GR  - U01 AG020480-06/AG/NIA NIH HHS/United States
GR  - U01 AG020480/AG/NIA NIH HHS/United States
GR  - U01-AG20480/AG/NIA NIH HHS/United States
GR  - U01 AG020480-03/AG/NIA NIH HHS/United States
GR  - U01 AG020480-01/AG/NIA NIH HHS/United States
GR  - U01 AG020480-07/AG/NIA NIH HHS/United States
GR  - U01 AG020480-04/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Adult
MH  - Body Weight
MH  - Caloric Restriction/*methods
MH  - Dietary Fiber/*administration & dosage/adverse effects
MH  - *Edible Grain
MH  - Energy Metabolism
MH  - Female
MH  - Humans
MH  - Hunger
MH  - Male
MH  - Motor Activity
MH  - Overweight/*diet therapy/metabolism
MH  - Satiety Response
MH  - Young Adult
PMC - PMC2869218
MID - NIHMS187851
EDAT- 2009/01/31 09:00
MHDA- 2009/03/31 09:00
PMCR- 2010/05/13
CRDT- 2009/01/31 09:00
PHST- 2009/01/31 09:00 [entrez]
PHST- 2009/01/31 09:00 [pubmed]
PHST- 2009/03/31 09:00 [medline]
PHST- 2010/05/13 00:00 [pmc-release]
AID - 5316 [pii]
AID - 10.1007/BF03324878 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2008 Dec;20(6):513-20. doi: 10.1007/BF03324878.