PMID- 19181292
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20151119
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 1
DP  - 2009 Feb
TI  - Prognostic value of combined measurement of brain natriuretic peptide and 
      triiodothyronine in heart failure.
PG  - 35-40
LID - 10.1016/j.cardfail.2008.08.008 [doi]
AB  - BACKGROUND: Both low free triiodothyronine (fT3) and high brain natriuretic 
      peptide (BNP) have been separately described as prognostic predictors for 
      mortality in heart failure (HF). We investigated whether their prognostic value 
      is independent. METHODS AND RESULTS: From January of 2001 to December of 2006, we 
      prospectively evaluated 442 consecutive patients with systolic HF and no thyroid 
      disease or treatment with drugs affecting thyroid function (age 65+/-12 years, 
      mean +/- standard deviation, 75% were male, left ventricular ejection fraction 
      33% +/- 10%, New York Heart Association (NYHA) class I and II: 63%, NYHA class 
      III and IV: 37%). All patients underwent full clinical and echocardiographic 
      evaluation and assessment of BNP and thyroid function. Both cardiac and all-cause 
      mortality (cumulative) were considered as end points. During a median 36-month 
      follow-up (range 1-86 months), 110 patients (24.8%) died, 64 (14.4%) of cardiac 
      causes. Univariate Cox model predictors of all-cause mortality and cardiac death 
      were age, body mass index, creatinine, hemoglobin, ejection fraction, NYHA class, 
      BNP, fT3, and thyroxine level. Multivariate analysis selected age, NYHA class, 
      hemoglobin, BNP, and fT3 as independent predictors for all-cause mortality and 
      NYHA class, BNP, and fT3 as independent predictors for cardiac mortality. 
      Patients with low fT3 and higher BNP showed the highest risk of all-cause and 
      cardiac death (odds ratio 11.6, confidence interval, 5.8-22.9; odds ratio 13.8, 
      confidence interval, 5.4-35.2, respectively, compared with patients with normal 
      fT3 and low BNP). CONCLUSION: fT3 and BNP hold an independent and additive 
      prognostic value in HF.
FAU - Passino, Claudio
AU  - Passino C
AD  - Department of Cardiovascular Medicine, G. Monasterio Foundation, CNR-Institute of 
      Clinical Physiology, Pisa, Italy.
FAU - Pingitore, Alessandro
AU  - Pingitore A
FAU - Landi, Patrizia
AU  - Landi P
FAU - Fontana, Marianna
AU  - Fontana M
FAU - Zyw, Luc
AU  - Zyw L
FAU - Clerico, Aldo
AU  - Clerico A
FAU - Emdin, Michele
AU  - Emdin M
FAU - Iervasi, Giorgio
AU  - Iervasi G
LA  - eng
PT  - Journal Article
DEP - 20081004
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Biomarkers)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure, Systolic/blood/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/*blood
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reference Values
MH  - Risk Assessment
MH  - Stroke Volume
MH  - Survival Analysis
MH  - Thyroxine/blood
MH  - Triiodothyronine/*blood
MH  - Ventricular Function, Left
EDAT- 2009/02/03 09:00
MHDA- 2010/05/08 06:00
CRDT- 2009/02/03 09:00
PHST- 2008/05/13 00:00 [received]
PHST- 2008/08/13 00:00 [revised]
PHST- 2008/08/25 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
AID - S1071-9164(08)00978-0 [pii]
AID - 10.1016/j.cardfail.2008.08.008 [doi]
PST - ppublish
SO  - J Card Fail. 2009 Feb;15(1):35-40. doi: 10.1016/j.cardfail.2008.08.008. Epub 2008 
      Oct 4.