PMID- 19181453
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20181201
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 34
IP  - 6
DP  - 2009 Jul
TI  - Pre-pubertal stress exposure affects adult behavioral response in association 
      with changes in circulating corticosterone and brain-derived neurotrophic factor.
PG  - 844-58
LID - 10.1016/j.psyneuen.2008.12.018 [doi]
AB  - Early-life stress produces a cascade of neurobiological events that cause 
      enduring changes in neural plasticity and synaptic efficacy that appear to play 
      pivotal roles in the pathophysiology of post-traumatic stress disorder (PTSD). 
      Brain-derived neurotrophic factor (BDNF) has been implicated in the 
      neurobiological mechanisms of these changes, in interaction with components of 
      the stress response, such as corticosterone. This study examined the consequences 
      of juvenile stress for behavior during adulthood in association with circulating 
      corticosterone levels and BDNF expression. The experiments examined single 
      exposure to predator scent stress (soiled cat litter for 10 min) as compared to 
      repeated exposure, early in life and later on. Behavioral responses were assessed 
      in the elevated plus maze and the acoustic startle response paradigms at 28, 60 
      and 90 days of age. Plasma corticosterone was measured and brain areas analyzed 
      for BDNF levels. The results show that juvenile stress exposure increased 
      anxiety-like behavior and startle amplitude and decreased plasma corticosterone. 
      This response was seen immediately after exposure and also long term. Adult 
      stress exposure increased anxiety-like behavior, startle amplitude and plasma 
      corticosterone. Exposure to both early and later life trauma elicited reduced 
      levels of corticosterone following the initial exposure, which were not raised by 
      re-exposure, and elicited significant downregulation of BDNF mRNA and protein 
      levels in the hippocampus CA1 subregion. The consequences of adult stress 
      exposure were more severe in rats were exposed to the same stressor as juveniles, 
      indicated increased vulnerability. The results suggest that juvenile stress has 
      resounding effects in adulthood reflected in behavioral responses. The 
      concomitant changes in BDNF and corticosterone levels may mediate the changes in 
      neural plasticity and synaptic functioning underlying clinical manifestations of 
      PTSD.
FAU - Bazak, Noam
AU  - Bazak N
AD  - Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, 
      Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 4600, 
      Beer-Sheva 84170, Beer-Sheva, Israel.
FAU - Kozlovsky, Nitsan
AU  - Kozlovsky N
FAU - Kaplan, Zeev
AU  - Kaplan Z
FAU - Matar, Michael
AU  - Matar M
FAU - Golan, Hava
AU  - Golan H
FAU - Zohar, Joseph
AU  - Zohar J
FAU - Richter-Levin, Gal
AU  - Richter-Levin G
FAU - Cohen, Hagit
AU  - Cohen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090131
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Algorithms
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain/metabolism/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics/metabolism
MH  - Corticosterone/*blood/metabolism
MH  - Exploratory Behavior/physiology
MH  - Food Chain
MH  - Male
MH  - Maze Learning
MH  - Neuronal Plasticity/genetics/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex, Startle/physiology
MH  - Sexual Maturation/*physiology
MH  - Stress Disorders, Post-Traumatic/etiology/genetics/physiopathology
MH  - Stress, Psychological/*blood/physiopathology
EDAT- 2009/02/03 09:00
MHDA- 2009/08/26 09:00
CRDT- 2009/02/03 09:00
PHST- 2008/05/12 00:00 [received]
PHST- 2008/11/30 00:00 [revised]
PHST- 2008/12/30 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
AID - S0306-4530(09)00002-X [pii]
AID - 10.1016/j.psyneuen.2008.12.018 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2009 Jul;34(6):844-58. doi: 
      10.1016/j.psyneuen.2008.12.018. Epub 2009 Jan 31.