PMID- 19181772
OWN - NLM
STAT- MEDLINE
DCOM- 20090625
LR  - 20220410
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 87
IP  - 5
DP  - 2009 May
TI  - Clinical and pathological responses of pigs from two genetically diverse 
      commercial lines to porcine reproductive and respiratory syndrome virus 
      infection.
PG  - 1638-47
LID - 10.2527/jas.2008-1447 [doi]
AB  - The response to infection from porcine reproductive and respiratory syndrome 
      virus (PRRSV) for 2 genetically diverse commercial pig lines was investigated. 
      Seventy-two pigs from each line, aged 6 wk, were challenged with PRRSV VR-2385, 
      and 66 litter-mates served as control. The clinical response to infection was 
      monitored throughout the study and pigs were necropsied at 10 or 21 d 
      postinfection. Previous analyses showed significant line differences in 
      susceptibility to PRRSV infection. This study also revealed significant line 
      differences in growth during infection. Line B, characterized by faster growth 
      rate than line A in the absence of infection, suffered more severe clinical 
      disease and greater reduction in BW growth after infection. Correlations between 
      growth and disease-related traits were generally negative, albeit weak. 
      Correlations were also weak among most clinical and pathological traits. Clinical 
      disease traits such as respiratory scores and rectal temperatures were poor 
      indicators of virus levels, pathological damage, or growth during PRRSV 
      infection. Relationships between traits varied over time, indicating that 
      different disease-related mechanisms may operate at different time scales and, 
      therefore, that the time of assessing host responses may influence the 
      conclusions drawn about biological significance. Three possible mechanisms 
      underlying growth under PRRSV infection were proposed based on evidence from this 
      and previous studies. It was concluded that a comprehensive framework describing 
      the interaction between the biological mechanisms and the genetic influence on 
      these would be desirable for achieving progress in the genetic control of this 
      economically important disease.
FAU - Doeschl-Wilson, A B
AU  - Doeschl-Wilson AB
AD  - Scottish Agricultural College, Sustainable Livestock Systems, King's Buildings, 
      West-Mains Road Edinburgh, EH9 3JG, United Kingdom. Andrea.Wilson@sac.ac.uk
FAU - Kyriazakis, I
AU  - Kyriazakis I
FAU - Vincent, A
AU  - Vincent A
FAU - Rothschild, M F
AU  - Rothschild MF
FAU - Thacker, E
AU  - Thacker E
FAU - Galina-Pantoja, L
AU  - Galina-Pantoja L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090130
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Female
MH  - Fever
MH  - Least-Squares Analysis
MH  - Male
MH  - Pneumonia/*veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/physiology
MH  - Random Allocation
MH  - Respiratory System/pathology
MH  - Swine/*genetics
EDAT- 2009/02/03 09:00
MHDA- 2009/06/26 09:00
CRDT- 2009/02/03 09:00
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/06/26 09:00 [medline]
AID - jas.2008-1447 [pii]
AID - 10.2527/jas.2008-1447 [doi]
PST - ppublish
SO  - J Anim Sci. 2009 May;87(5):1638-47. doi: 10.2527/jas.2008-1447. Epub 2009 Jan 30.