PMID- 19182380
OWN - NLM
STAT- MEDLINE
DCOM- 20090312
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 32
IP  - 2
DP  - 2009 Feb
TI  - The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor 
      dysfunction in rats.
PG  - 225-31
AB  - The present study investigated the effect of 
      4[(5,6,7,8-tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)carbamoyl] benzoic acid 
      (Am-80), a synthetic retinoid, on spinal cord injury (SCI) in rats. Treatment 
      with Am-80 (orally and subcutaneously) significantly promoted recovery from 
      SCI-induced motor dysfunction. On day 28 after injury, the lesion cavity was 
      markedly reduced, while the expression of myelin basic protein (MBP; myelin), 
      betaIIItubulin (neuron), and glial fibrillary acidic protein (GFAP; astrocyte) 
      was increased, in comparison with SCI controls. Interestingly, expression of 
      neurotrophin receptor, tyrosine kinase B (TrkB) was over 3-fold higher after 
      Am-80 treatment than in SCI controls. A lot of TrkB-positive cells as well as 
      brain-derived neurotrophic factor (BDNF)-positive ones were observed around the 
      injured site. Am-80 (10 microM) combined with BDNF (100 ng/ml) promoted extensive 
      neurite outgrowth and TrkB gene expression by cultured SH-SY5Y cells, as did 
      all-trans retinoic acid (ATRA). Thymidine incorporation was dramatically 
      suppressed, but there was little effect on cell viability. These findings suggest 
      that Am-80 has the potential to be used for treating neurodegenerative disorders, 
      including SCI. Its efficacy may be partly ascribed to promotion of cell viability 
      and differentiation of neural stem cells through increased TrkB expression.
FAU - Takenaga, Mitsuko
AU  - Takenaga M
AD  - Institute of Medical Science, St. Marianna University School of Medicine, 
      Kawasaki, Japan. m2take@marianna-u.ac.jp
FAU - Ohta, Yuki
AU  - Ohta Y
FAU - Tokura, Yukie
AU  - Tokura Y
FAU - Hamaguchi, Akemi
AU  - Hamaguchi A
FAU - Shudo, Koichi
AU  - Shudo K
FAU - Okano, Hideyuki
AU  - Okano H
FAU - Igarashi, Rie
AU  - Igarashi R
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Benzoates)
RN  - 0 (Biomarkers)
RN  - 0 (Keratolytic Agents)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Retinoids)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 08V52GZ3H9 (tamibarotene)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Benzoates/*pharmacology
MH  - Biomarkers
MH  - Blotting, Western
MH  - Cell Differentiation/drug effects
MH  - Cell Line, Tumor
MH  - Female
MH  - Hindlimb/innervation/physiology
MH  - Humans
MH  - Keratolytic Agents/pharmacology
MH  - Locomotion/drug effects
MH  - Movement Disorders/*drug therapy/etiology/*physiopathology
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Neurons/drug effects/ultrastructure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retinoids/*pharmacology
MH  - Spinal Cord Injuries/complications/*drug therapy/*physiopathology
MH  - Tetrahydronaphthalenes/*pharmacology
MH  - Tretinoin/pharmacology
EDAT- 2009/02/03 09:00
MHDA- 2009/03/13 09:00
CRDT- 2009/02/03 09:00
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/03/13 09:00 [medline]
AID - JST.JSTAGE/bpb/32.225 [pii]
AID - 10.1248/bpb.32.225 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2009 Feb;32(2):225-31. doi: 10.1248/bpb.32.225.