PMID- 19183400
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20191210
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 18
IP  - 3
DP  - 2009 Mar
TI  - Dendritic cells--why can they help and hurt us.
PG  - 264-73
LID - 10.1111/j.1600-0625.2008.00823.x [doi]
AB  - Dendritic cells (DCs) show a Janus-like functional behavior. They help us by 
      their orchestration of numerous immune responses to defend our body against 
      invading pathogenic micro-organisms and also induce regulatory T cells to inhibit 
      immune reactions against autoantigens as well as diverse harmless environmental 
      antigens. However, DCs can also be of harm to us when misguided by their 
      microenvironment as in allergic and autoimmune diseases or when DCs are targeted 
      and exploited by microbes and cancer cells to evade the immune defense. This huge 
      and diverse functional repertoire of DCs requires complex decision-making 
      processes and the integration of multiple stimulatory and inhibitory signals. 
      Although a given DC type has an extensive functionally plasticity, DCs are 
      heterogeneous and individual DC subtypes are differentially distributed in 
      tissues, express distinct sets of pattern recognition receptors and differ in 
      their capacity to program naive T cells. With the help of transgenic mouse models 
      and selective ablation of individual DC subtypes, we are just at the beginning of 
      understanding the DC system in its complexity. Obtaining a more detailed 
      knowledge of the DC system in mice and men holds strong promise for the 
      successful induction of immunity and tolerance in therapeutic trials. This review 
      presents the recent advances in the understanding of DC biology and discusses why 
      and how DC can help and hurt us.
FAU - Schakel, Knut
AU  - Schakel K
AD  - Department of Dermatology, Medical Faculty, Technische Universitat Dresden, 
      Dresden, Germany. knut.schaekel@tu-dresden.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090124
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Animals
MH  - Autoimmunity/immunology
MH  - Dendritic Cells/*immunology/*physiology
MH  - Disease Models, Animal
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immune System/*physiology
MH  - Infections/immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neoplasms/immunology
RF  - 121
EDAT- 2009/02/03 09:00
MHDA- 2009/08/18 09:00
CRDT- 2009/02/03 09:00
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
AID - EXD823 [pii]
AID - 10.1111/j.1600-0625.2008.00823.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2009 Mar;18(3):264-73. doi: 10.1111/j.1600-0625.2008.00823.x. Epub 
      2009 Jan 24.