PMID- 19183490
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20211020
IS  - 1756-6606 (Electronic)
IS  - 1756-6606 (Linking)
VI  - 2
DP  - 2009 Jan 31
TI  - Influence of brain-derived neurotrophic factor on pathfinding of dentate granule 
      cell axons, the hippocampal mossy fibers.
PG  - 2
LID - 10.1186/1756-6606-2-2 [doi]
AB  - Mossy fibers, the dentate granule cell axons, are generated throughout an 
      animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the 
      stratum lucidum within the CA3 region. Brain-derived neurotrophic factor (BDNF), 
      a neurotrophin family protein that activates Trk neurotrophin receptors, is 
      highly expressed in the stratum lucidum in an activity-dependent manner. The 
      addition of a Trk neurotrophin receptor inhibitor, K252a, to cultured hippocampal 
      slices induced aberrant extension of mossy fibers into ectopic regions. BDNF 
      overexpression in granule cells ameliorated the mossy fiber pathway abnormalities 
      caused by a submaximal dose of K252a. A similar rescue was observed when BDNF was 
      expressed in CA3 pyramidal cells, most notably in mossy fibers distal to the 
      expression site. These findings are the first to clarify the role of BDNF in 
      mossy fiber pathfinding, not as an attractant cue but as a regulator, possibly 
      acting in a paracrine manner. This effect of BDNF may be as a signal for new 
      fibers to fasciculate and extend further to form synapses with neurons that are 
      far from active BDNF-expressing synapses. This mechanism would ensure the 
      emergence of new independent dentate gyrus-CA3 circuits by the axons of new-born 
      granule cells.
FAU - Tamura, Makoto
AU  - Tamura M
AD  - Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, 
      The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan. 
      mtamura44@gmail.com
FAU - Tamura, Naohiro
AU  - Tamura N
FAU - Ikeda, Takamitsu
AU  - Ikeda T
FAU - Koyama, Ryuta
AU  - Koyama R
FAU - Ikegaya, Yuji
AU  - Ikegaya Y
FAU - Matsuki, Norio
AU  - Matsuki N
FAU - Yamada, Maki K
AU  - Yamada MK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090131
PL  - England
TA  - Mol Brain
JT  - Molecular brain
JID - 101468876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Peptides)
RN  - 97161-97-2 (staurosporine aglycone)
SB  - IM
MH  - Animals
MH  - Axons/drug effects/*metabolism
MH  - Biological Assay
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbazoles/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - HEK293 Cells
MH  - Humans
MH  - Indole Alkaloids/pharmacology
MH  - Mossy Fibers, Hippocampal/drug effects/*metabolism
MH  - Peptides/metabolism
MH  - Pyramidal Cells/metabolism
MH  - Rats
PMC - PMC2642816
EDAT- 2009/02/03 09:00
MHDA- 2011/05/03 06:00
PMCR- 2009/01/31
CRDT- 2009/02/03 09:00
PHST- 2008/10/15 00:00 [received]
PHST- 2009/01/31 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
PHST- 2009/01/31 00:00 [pmc-release]
AID - 1756-6606-2-2 [pii]
AID - 10.1186/1756-6606-2-2 [doi]
PST - epublish
SO  - Mol Brain. 2009 Jan 31;2:2. doi: 10.1186/1756-6606-2-2.