PMID- 19184004
OWN - NLM
STAT- MEDLINE
DCOM- 20090731
LR  - 20211020
IS  - 1432-0851 (Electronic)
IS  - 0340-7004 (Print)
IS  - 0340-7004 (Linking)
VI  - 58
IP  - 9
DP  - 2009 Sep
TI  - Amyloid precursor-like protein 2 association with HLA class I molecules.
PG  - 1419-31
LID - 10.1007/s00262-009-0657-z [doi]
AB  - Amyloid precursor-like protein 2 (APLP2) is a ubiquitously expressed protein. The 
      previously demonstrated functions for APLP2 include binding to the mouse major 
      histocompatibility complex (MHC) class I molecule H-2K(d) and down regulating its 
      cell surface expression. In this study, we have investigated the interaction of 
      APLP2 with the human leukocyte antigen (HLA) class I molecule in human tumor cell 
      lines. APLP2 was readily detected in pancreatic, breast, and prostate tumor 
      lines, although it was found only in very low amounts in lymphoma cell lines. In 
      a pancreatic tumor cell line, HLA class I was extensively co-localized with APLP2 
      in vesicular compartments following endocytosis of HLA class I molecules. In 
      pancreatic, breast, and prostate tumor lines, APLP2 was bound to the HLA class I 
      molecule. APLP2 was found to bind to HLA-A24, and more strongly to HLA-A2. 
      Increased expression of APLP2 resulted in reduced surface expression of HLA-A2 
      and HLA-A24. Overall, these studies demonstrate that APLP2 binds to the HLA class 
      I molecule, co-localizes with it in intracellular vesicles, and reduces the level 
      of HLA class I molecule cell surface expression.
FAU - Tuli, Amit
AU  - Tuli A
AD  - Eppley Institute for Research in Cancer and Allied Diseases, University of 
      Nebraska Medical Center, Omaha, NE, USA.
FAU - Sharma, Mahak
AU  - Sharma M
FAU - Wang, Xiaojian
AU  - Wang X
FAU - Simone, Laura C
AU  - Simone LC
FAU - Capek, Haley L
AU  - Capek HL
FAU - Cate, Steven
AU  - Cate S
FAU - Hildebrand, William H
AU  - Hildebrand WH
FAU - Naslavsky, Naava
AU  - Naslavsky N
FAU - Caplan, Steve
AU  - Caplan S
FAU - Solheim, Joyce C
AU  - Solheim JC
LA  - eng
GR  - R01 GM074876-03/GM/NIGMS NIH HHS/United States
GR  - GM74876/GM/NIGMS NIH HHS/United States
GR  - T32 CA009476-19A1/CA/NCI NIH HHS/United States
GR  - R01 GM057428/GM/NIGMS NIH HHS/United States
GR  - GM57428/GM/NIGMS NIH HHS/United States
GR  - R01 GM057428-09/GM/NIGMS NIH HHS/United States
GR  - P30 CA036727/CA/NCI NIH HHS/United States
GR  - P30CA036727/CA/NCI NIH HHS/United States
GR  - R01 GM074876/GM/NIGMS NIH HHS/United States
GR  - T32 CA009476/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090131
PL  - Germany
TA  - Cancer Immunol Immunother
JT  - Cancer immunology, immunotherapy : CII
JID - 8605732
RN  - 0 (APLP2 protein, human)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
EIN - Cancer Immunol Immunother. 2010 Feb;59(2):339
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Blotting, Western
MH  - Cell Membrane/*metabolism
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - HLA-A Antigens/*metabolism
MH  - HLA-A2 Antigen/*metabolism
MH  - HLA-A24 Antigen
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Immunoprecipitation
MH  - Neoplasms/*metabolism/pathology
MH  - Nerve Tissue Proteins/*metabolism
MH  - Tumor Cells, Cultured
PMC - PMC2719714
MID - NIHMS101247
EDAT- 2009/02/03 09:00
MHDA- 2009/08/01 09:00
PMCR- 2009/01/31
CRDT- 2009/02/03 09:00
PHST- 2008/10/08 00:00 [received]
PHST- 2009/01/02 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/08/01 09:00 [medline]
PHST- 2009/01/31 00:00 [pmc-release]
AID - 657 [pii]
AID - 10.1007/s00262-009-0657-z [doi]
PST - ppublish
SO  - Cancer Immunol Immunother. 2009 Sep;58(9):1419-31. doi: 
      10.1007/s00262-009-0657-z. Epub 2009 Jan 31.