PMID- 19185547
OWN - NLM
STAT- MEDLINE
DCOM- 20090626
LR  - 20161125
IS  - 1872-7484 (Electronic)
IS  - 1566-0702 (Linking)
VI  - 147
IP  - 1-2
DP  - 2009 May 11
TI  - The medial forebrain bundle mediates cardiovascular responses to electrical 
      stimulation of the medial prefrontal cortex.
PG  - 38-47
LID - 10.1016/j.autneu.2009.01.001 [doi]
AB  - The medial prefrontal cortex (MPFC) is involved in cardiovascular control. MPFC 
      electrical stimulation has been reported to cause depressor and bradycardic 
      responses in anesthetized rats. Although the pathway involved is yet unknown, 
      there is evidence indicating the existence of a relay in the lateral hypothalamus 
      (LH). The medial forebrain bundle (MFB) that courses in the lateral portion of 
      the LH carries the vast majority of telencephalic afferent as well efferent 
      projections, including those from the MPFC. To evaluate if the hypotensive 
      pathway originating in the MPFC courses the MFB, we studied the effect of coronal 
      or sagittal knife cuts through the LH and other brain areas on the cardiovascular 
      responses to MPFC electrical stimulation. Knife cuts were performed using blades 
      1 to 6 mm wide. Results indicate that the neural pathway descending from the MFB 
      decussates early in the vicinity of MPFC, crossing the midline within the corpus 
      callosum and yielding two descending pathways that travel rostro-caudally in the 
      lateral portion of the LH, within the MFB. The decussation was confirmed by 
      histological analysis of brain sections processed after the injection of 
      biotinilated dextran amine in the site of the stimulation in the MPFC. Because 
      knife cuts through the LH ipsilateral had minimal effects on the cardiovascular 
      responses and knife cuts performed contralateral to the stimulated MPFC had no 
      effect on the response to MPFC stimulation, data indicate that the contralateral 
      limb of the pathway may be only activated as an alternative pathway when the 
      ipsilateral pathway is blocked.
FAU - Scopinho, America Augusto
AU  - Scopinho AA
AD  - Department of Pharmacology, School of Medicine of Ribeirao Preto, University of 
      Sao Paulo, Ribeirao Preto, SP, 14090-090, Brazil.
FAU - Tavares, Rodrigo Fiacadori
AU  - Tavares RF
FAU - Correa, Fernando Morgan Aguiar
AU  - Correa FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090129
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
RN  - 0 (Dextrans)
RN  - 0 (biotinylated dextran amine)
RN  - 6SO6U10H04 (Biotin)
SB  - IM
MH  - Animals
MH  - Autonomic Pathways/anatomy & histology/*physiology
MH  - Biotin/analogs & derivatives
MH  - Brain Mapping
MH  - *Cardiovascular Physiological Phenomena
MH  - Denervation
MH  - Dextrans
MH  - Diencephalon/anatomy & histology/*physiology
MH  - Efferent Pathways/anatomy & histology/physiology
MH  - Electric Stimulation
MH  - Functional Laterality/physiology
MH  - Hypothalamic Area, Lateral/anatomy & histology/physiology
MH  - Male
MH  - Medial Forebrain Bundle/anatomy & histology/*physiology
MH  - Prefrontal Cortex/anatomy & histology/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Staining and Labeling
EDAT- 2009/02/03 09:00
MHDA- 2009/06/27 09:00
CRDT- 2009/02/03 09:00
PHST- 2008/03/20 00:00 [received]
PHST- 2008/12/30 00:00 [revised]
PHST- 2009/01/05 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2009/06/27 09:00 [medline]
AID - S1566-0702(09)00004-6 [pii]
AID - 10.1016/j.autneu.2009.01.001 [doi]
PST - ppublish
SO  - Auton Neurosci. 2009 May 11;147(1-2):38-47. doi: 10.1016/j.autneu.2009.01.001. 
      Epub 2009 Jan 29.