PMID- 19187265
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20240312
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 29
IP  - 3
DP  - 2009 Feb
TI  - A direct main olfactory bulb projection to the 'vomeronasal' amygdala in female 
      mice selectively responds to volatile pheromones from males.
PG  - 624-34
LID - 10.1111/j.1460-9568.2009.06638.x [doi]
AB  - The main olfactory system, like the accessory olfactory system, responds to 
      pheromones involved in social communication. Whereas pheromones detected by the 
      accessory system are transmitted to the hypothalamus via the medial 
      ('vomeronasal') amygdala, the pathway by which pheromones are detected and 
      transmitted by the main system is not well understood. We examined in female mice 
      whether a direct projection from mitral/tufted (M/T) cells in the main olfactory 
      bulb (MOB) to the medial amygdala exists, and whether medial amygdala-projecting 
      M/T cells are activated by volatile urinary odors from conspecifics or a predator 
      (cat). Simultaneous anterograde tracing using Phaseolus vulgaris leucoagglutinin 
      and Fluoro-Ruby placed in the MOB and accessory olfactory bulb (AOB), 
      respectively, revealed that axons of MOB M/T cells projected to superficial 
      laminae of layer Ia in anterior and posterodorsal subdivisions of the medial 
      amygdala, whereas projection neurons from the AOB sent axons to non-overlapping, 
      deeper layer Ia laminae of the same subdivisions. Placement of the retrograde 
      tracer cholera toxin B into the medial amygdala labeled M/T cells that were 
      concentrated in the ventral MOB. Urinary volatiles from male mice, but not from 
      female conspecifics or cat, induced Fos in medial amygdala-projecting MOB M/T 
      cells of female subjects, suggesting that information about male odors is 
      transmitted directly from the MOB to the 'vomeronasal' amygdala. The presence of 
      a direct MOB-to-medial amygdala pathway in mice and other mammals could enable 
      volatile, opposite-sex pheromones to gain privileged access to diencephalic 
      structures that control mate recognition and reproduction.
FAU - Kang, Ningdong
AU  - Kang N
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Baum, Michael J
AU  - Baum MJ
FAU - Cherry, James A
AU  - Cherry JA
LA  - eng
GR  - R01 HD021094/HD/NICHD NIH HHS/United States
GR  - HD 21094/HD/NICHD NIH HHS/United States
GR  - HD 044897/HD/NICHD NIH HHS/United States
GR  - R01 HD044897-05/HD/NICHD NIH HHS/United States
GR  - R01 HD044897-06/HD/NICHD NIH HHS/United States
GR  - R01 HD021094-18/HD/NICHD NIH HHS/United States
GR  - R01 HD044897/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090128
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Sex Attractants)
SB  - IM
CIN - Eur J Neurosci. 2009 Feb;29(3):623. PMID: 19222561
MH  - Amygdala/*cytology/physiology
MH  - Animals
MH  - Brain Mapping
MH  - Female
MH  - Fluorescent Dyes
MH  - Male
MH  - Mice
MH  - Odorants
MH  - Olfactory Bulb/*cytology/physiology
MH  - Olfactory Pathways/*cytology/physiology
MH  - Sex Attractants/*physiology
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/physiology
MH  - Smell/*physiology
MH  - Staining and Labeling
MH  - Vomeronasal Organ/*cytology/physiology
PMC - PMC2669936
MID - NIHMS100470
EDAT- 2009/02/04 09:00
MHDA- 2009/06/13 09:00
PMCR- 2010/02/01
CRDT- 2009/02/04 09:00
PHST- 2009/02/04 09:00 [entrez]
PHST- 2009/02/04 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
PHST- 2010/02/01 00:00 [pmc-release]
AID - EJN6638 [pii]
AID - 10.1111/j.1460-9568.2009.06638.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Feb;29(3):624-34. doi: 10.1111/j.1460-9568.2009.06638.x. 
      Epub 2009 Jan 28.