PMID- 19187587
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20220309
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 121
IP  - 24
DP  - 2008 Dec 20
TI  - High sensitive C-reactive protein, adiponectin, and urine albumin excretion rate 
      in Chinese coronary artery disease patients with different glucose tolerance 
      status.
PG  - 2509-16
AB  - BACKGROUND: Serum high sensitive C-reactive protein (hs-CRP), adiponectin levels 
      and urine albumin excretion rate (UAER) are probably associated with inflammation 
      and atherosclerosis. The aim of this study was to determine the three markers in 
      coronary artery disease (CAD) subjects with different glucose tolerance status in 
      a Chinese population and further explore the levels of the three markers in these 
      subjects and the possible association of these markers with CAD risk factors and 
      the severity of CAD as well. METHODS: A total of 242 subjects with 
      angiographically documented CAD were recruited, and then assigned to three 
      groups: the normal glucose tolerance (NGT) + CAD group, including 100 CAD 
      patients with NGT; the impaired glucose tolerance (IGT) + CAD group, 40 CAD 
      patients with IGT; the type 2 diabetes mellitus (T2DM) + CAD group, 102 CAD 
      patients with T2DM. Serum hs-CRP, adiponectin levels as well as UAER were 
      measured in all subjects. RESULTS: Serum hs-CRP levels were increased in the T2DM 
      + CAD group compared with the NGT + CAD group (4.71 +/- 2.59) vs (3.60 +/- 2.46) 
      mg/L, P = 0.037. Serum adiponectin levels were gradually decreased from the NGT + 
      CAD to IGT + CAD to T2DM + CAD groups, (5.99 +/- 1.84), (5.82 +/- 1.72) and (4.65 
      +/- 1.71) mg/L, P = 0.002 and 0.040 for NGT + CAD and IGT + CAD groups vs T2DM + 
      CAD group, respectively. While the UAER was gradually increased from the NGT + 
      CAD to IGT + CAD to T2DM + CAD groups, (6.42 +/- 2.51), (6.89 +/- 2.94) and 
      (15.03 +/- 4.22) microg/min (P < 0.001) for NGT + CAD and IGT + CAD groups vs 
      T2DM + CAD group. Multiple linear stepwise regression analysis showed that 
      waist-hip ratio (WHR) and low density lipoprotein cholesterol (LDL-C) were the 
      significant determinants of serum hs-CRP levels; triglyceride (TG), high density 
      lipoprotein cholesterol (HDL-C), age, WHR, T2DM, 2-hour serum insulin (2hINS), 
      sex, and apolipoprotein B were the significant determinants of serum adiponectin 
      levels; and systolic blood pressure (SBP), T2DM, and hemoglobin A1c (HbA1c) were 
      the significant determinants of UAER in all subjects (R(2) = 0.070, 0.352, and 
      0.214, respectively). However, no significant correlation was seen for hs-CRP, 
      adiponectin and UAER with the severity of CAD. Hs-CRP levels were significantly 
      correlated with UAER. CONCLUSIONS: There was a trend of increased serum hs-CRP 
      levels from the NGT + CAD to IGT + CAD to T2DM + CAD groups, though it only 
      showed significance in the T2DM + CAD group compared with the NGT + CAD group. 
      Serum adiponectin levels were decreased and UAER was increased from the NGT + CAD 
      to IGT + CAD to T2DM + CAD groups. Increased UAER and serum hs-CRP, and decreased 
      adiponectin levels were associated with traditional CAD risk factors but failed 
      to be correlated with the severity of CAD. Hs-CRP levels were significantly 
      correlated with UAER.
FAU - Gui, Ming-hui
AU  - Gui MH
AD  - Department of Endocrinology and Metabolism, Shanghai Clinical Center for 
      Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic 
      Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Hong, Jie
AU  - Hong J
FAU - Lu, An-kang
AU  - Lu AK
FAU - Chen, Ying
AU  - Chen Y
FAU - Shen, Wei-feng
AU  - Shen WF
FAU - Li, Xiao-ying
AU  - Li XY
FAU - Ning, Guang
AU  - Ning G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Adiponectin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Albuminuria/*urine
MH  - C-Reactive Protein/*metabolism
MH  - Coronary Artery Disease/*blood/metabolism/*physiopathology/*urine
MH  - Female
MH  - Glucose Intolerance/blood/urine
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2009/02/04 09:00
MHDA- 2009/03/28 09:00
CRDT- 2009/02/04 09:00
PHST- 2009/02/04 09:00 [entrez]
PHST- 2009/02/04 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2008 Dec 20;121(24):2509-16.