PMID- 19187780
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20090223
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 583
IP  - 4
DP  - 2009 Feb 18
TI  - Prominent expression of FRS2beta protein in neural cells and its association with 
      intracellular vesicles.
PG  - 807-14
LID - 10.1016/j.febslet.2009.01.042 [doi]
AB  - The fibroblast growth factor receptor substrate (FRS)-2 protein family comprises 
      FRS2alpha, a well-known central mediator for fibroblast growth factor signaling, 
      and FRS2beta, whose endogenous expression pattern and function are not yet 
      defined. Immunohistochemical analysis revealed that expression of FRS2beta was 
      restricted to neural tissues and it colocalized with Tuj1, a neuronal marker. 
      There are two distinct patterns of FRS2beta expression in neural cells: punctate 
      and cup/ring-shaped; moreover, some particles colocalized with lysosomes. 
      Stimulation with brain-derived neurotrophic factor (BDNF) enhanced FRS2beta 
      phosphorylation and the cup/ring-shaped pattern. These results suggest a probable 
      role of FRS2beta in the intracellular degradation systems of neural cells, which 
      involves lysosomes.
FAU - Minegishi, Yuriko
AU  - Minegishi Y
AD  - Division of Systems Biomedical Technology, Institute of Medical Science, The 
      University of Tokyo, 4-6-1, Shirokanedai Minato-ku, Tokyo 108-8639, Japan.
FAU - Iwanari, Hiroko
AU  - Iwanari H
FAU - Mochizuki, Yasuhiro
AU  - Mochizuki Y
FAU - Horii, Takako
AU  - Horii T
FAU - Hoshino, Tomoko
AU  - Hoshino T
FAU - Kodama, Tatsuhiko
AU  - Kodama T
FAU - Hamakubo, Takao
AU  - Hamakubo T
FAU - Gotoh, Noriko
AU  - Gotoh N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090131
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Frs3 protein, mouse)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/*metabolism
MH  - Animals
MH  - Antibodies, Monoclonal/metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology
MH  - Cytoplasmic Vesicles/*metabolism
MH  - Embryo, Mammalian
MH  - Fluorescent Antibody Technique, Direct
MH  - *Gene Expression Regulation, Developmental
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurons/*metabolism
EDAT- 2009/02/04 09:00
MHDA- 2009/03/21 09:00
CRDT- 2009/02/04 09:00
PHST- 2009/01/07 00:00 [received]
PHST- 2009/01/22 00:00 [revised]
PHST- 2009/01/22 00:00 [accepted]
PHST- 2009/02/04 09:00 [entrez]
PHST- 2009/02/04 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
AID - S0014-5793(09)00076-3 [pii]
AID - 10.1016/j.febslet.2009.01.042 [doi]
PST - ppublish
SO  - FEBS Lett. 2009 Feb 18;583(4):807-14. doi: 10.1016/j.febslet.2009.01.042. Epub 
      2009 Jan 31.