PMID- 19188711
OWN - NLM
STAT- MEDLINE
DCOM- 20090311
LR  - 20090203
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 122
IP  - 3-4
DP  - 2008
TI  - Distribution of (TTAGGG)n telomeric sequences in karyotypes of the Xenopus 
      species complex.
PG  - 396-400
LID - 10.1159/000167828 [doi]
AB  - The chromosomal distribution of the conserved vertebrate telomeric (TTAGGG)(n) 
      sequence was studied by fluorescence in situ hybridization (FISH) in four Xenopus 
      species and the triploid Silurana tropicalis. As expected, hybridization signals 
      were observed at the distal ends of every chromosome in all species. In addition, 
      the hybridization pattern demonstrates varied organization of (TTAGGG)(n) 
      sequences in the different karyotypes. In X. borealis and X. muelleri 
      hybridization signals intensely labeled one end of a homologous chromosome pair 
      that coincides with the sites containing ribosomal RNA gene clusters. The 
      karyotype of X. clivii remarkably differs from other Xenopus karyotypes in 
      displaying numerous interstitial telomeric sites (ITS). C-banding analysis shows 
      that the non-telomeric sites appear to correspond to the interstitially located 
      constitutive heterochromatin. This suggests that interstitial telomeric sites in 
      X. clivii do not necessarily represent the relic of ancestral telomeres resulting 
      from the fusion of chromosomes, but their occurrence is due to the fact that 
      (TTAGGG)(n) repeat arrays may be a constituent of highly repetitive DNA.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Nanda, I
AU  - Nanda I
AD  - Department of Human Genetics, University of Wurzburg, Wurzburg, Germany.
FAU - Fugate, M
AU  - Fugate M
FAU - Steinlein, C
AU  - Steinlein C
FAU - Schmid, M
AU  - Schmid M
LA  - eng
PT  - Journal Article
DEP - 20090130
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
RN  - 0 (Oligodeoxyribonucleotides)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Banding
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Metaphase/genetics
MH  - Oligodeoxyribonucleotides
MH  - Polyploidy
MH  - Telomere/*genetics/ultrastructure
MH  - Xenopus/*genetics
MH  - Xenopus laevis/genetics
EDAT- 2009/02/04 09:00
MHDA- 2009/03/12 09:00
CRDT- 2009/02/04 09:00
PHST- 2008/09/08 00:00 [accepted]
PHST- 2009/02/04 09:00 [entrez]
PHST- 2009/02/04 09:00 [pubmed]
PHST- 2009/03/12 09:00 [medline]
AID - 000167828 [pii]
AID - 10.1159/000167828 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2008;122(3-4):396-400. doi: 10.1159/000167828. Epub 2009 
      Jan 30.