PMID- 19189577 OWN - NLM STAT- MEDLINE DCOM- 20090317 LR - 20090204 IS - 0033-2240 (Print) IS - 0033-2240 (Linking) VI - 65 IP - 10 DP - 2008 TI - [Genes associated with tobacco smoke-associated cancer of head and neck]. PG - 680-3 AB - The article presents the current techniques used for the identification of genes involved in tobacco smoke-associated cancers. The focus is set on the techniques derived from the conventional cytogenetics and includes fluorescence in situ hybridization (FISH), comparative genomes hybridization (CGH) and its further improvement that is array-CGH, and other aspects of microarray DNA technology. The second part deals with the main findings concerning participation of oncogenes and tumor suppressor genes in development and progression of tobacco smoke-associated head and neck cancers. FAU - Szyfter, Krzysztof AU - Szyfter K AD - Instytut Genetyki Czlowieka PAN w Poznaniu. szyfkris@man.poznan.pl FAU - Giefing, Maciej AU - Giefing M FAU - Jarmuz, Malgorzata AU - Jarmuz M FAU - Kostrzewska-Poczekaj, Magdalena AU - Kostrzewska-Poczekaj M LA - pol PT - English Abstract PT - Journal Article PT - Review TT - Geny zwiazane z odtytoniowymi nowotworami glowy i szyi. PL - Poland TA - Przegl Lek JT - Przeglad lekarski JID - 19840720R SB - IM MH - Adult MH - Aged MH - Causality MH - Comorbidity MH - Disease Progression MH - Female MH - Gene Expression Regulation, Neoplastic/genetics MH - Genes, Tumor Suppressor/physiology MH - Head and Neck Neoplasms/*epidemiology/*genetics MH - Humans MH - Male MH - Middle Aged MH - Oligonucleotide Array Sequence Analysis/methods MH - Oncogenes/physiology MH - Smoking/*epidemiology RF - 52 EDAT- 2009/02/05 09:00 MHDA- 2009/03/18 09:00 CRDT- 2009/02/05 09:00 PHST- 2009/02/05 09:00 [entrez] PHST- 2009/02/05 09:00 [pubmed] PHST- 2009/03/18 09:00 [medline] PST - ppublish SO - Przegl Lek. 2008;65(10):680-3.