PMID- 19189863
OWN - NLM
STAT- MEDLINE
DCOM- 20090625
LR  - 20171116
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 9
IP  - 4
DP  - 2009 Apr
TI  - The shiitake mushroom-derived immuno-stimulant lentinan protects against murine 
      malaria blood-stage infection by evoking adaptive immune-responses.
PG  - 455-62
LID - 10.1016/j.intimp.2009.01.010 [doi]
AB  - Lentinan, a (1-3)-beta glucan from Lentinus edodes, is an effective 
      immunostimulatory drug. We tested the effects of lentinan during blood-stage 
      infection by Plasmodium yoelii 17XL (P.y17XL). Pre-treatment of mice with 
      lentinan significantly decreased the parasitemia and increased their survival 
      after infection. Enhanced IL-12, IFN-gamma and NO production induced by lentinan 
      in spleen cells of infected mice revealed that the Th1 immune response was 
      stimulated against malaria infection. In vitro and in vivo, lentinan can result 
      in enhanced expression of MHC II, CD80/CD86, and Toll-like receptors (TLR2/TLR4), 
      and increased production of IL-12 in spleen dendritic cells (DCs) co-cultured 
      with parasitized red blood cells (pRBCs). Moreover, both the number of 
      CD4(+)CD25(+) regulatory T cells (Tregs) and the levels of IL-10 secreted by 
      Tregs were reduced by pre-treatment with lentinan in the spleen of 
      malaria-infected mice. Meanwhile, apoptosis of CD4(+) T cell in spleens of mice 
      pretreated with lentinan was significantly reduced. In summary, lentinan can 
      induce protective Th1 immune responses to control the proliferation of malaria 
      parasites during the blood-stage of P.y17XL infection by stimulating maturation 
      of DCs to inhibit negative regulation of the Th1 immune response by Tregs. Taken 
      together, our findings suggest that lentinan has prophylactic potential for the 
      treatment of malaria.
FAU - Zhou, Lian-di
AU  - Zhou LD
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang, China.
FAU - Zhang, Qi-hui
AU  - Zhang QH
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Liu, Jun
AU  - Liu J
FAU - Cao, Ya-ming
AU  - Cao YM
LA  - eng
PT  - Journal Article
DEP - 20090202
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Cd86 protein, mouse)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Tlr2 protein, mouse)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 187348-17-0 (Interleukin-12)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37339-90-5 (Lentinan)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage/*therapeutic use
MH  - Animals
MH  - Apoptosis/drug effects/immunology
MH  - B7-1 Antigen/immunology/metabolism
MH  - B7-2 Antigen/immunology/metabolism
MH  - Cells, Cultured
MH  - Dendritic Cells/drug effects/immunology/metabolism/parasitology
MH  - Disease Models, Animal
MH  - Female
MH  - Histocompatibility Antigens Class II/immunology/metabolism
MH  - Interferon-gamma/agonists/immunology/metabolism
MH  - Interleukin-12/agonists/immunology/metabolism
MH  - Lentinan/administration & dosage/*therapeutic use
MH  - Malaria/complications/*drug therapy/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nitric Oxide/agonists/immunology/metabolism
MH  - Parasitemia/etiology/immunology/*prevention & control
MH  - *Plasmodium yoelii
MH  - Shiitake Mushrooms/chemistry
MH  - T-Lymphocytes, Regulatory/drug effects/immunology/metabolism/parasitology
MH  - Th1 Cells/drug effects/immunology/metabolism/parasitology
MH  - Toll-Like Receptor 2/agonists/immunology/metabolism
MH  - Toll-Like Receptor 4/agonists/immunology/metabolism
EDAT- 2009/02/05 09:00
MHDA- 2009/06/26 09:00
CRDT- 2009/02/05 09:00
PHST- 2008/08/04 00:00 [received]
PHST- 2008/12/22 00:00 [revised]
PHST- 2009/01/19 00:00 [accepted]
PHST- 2009/02/05 09:00 [entrez]
PHST- 2009/02/05 09:00 [pubmed]
PHST- 2009/06/26 09:00 [medline]
AID - S1567-5769(09)00025-3 [pii]
AID - 10.1016/j.intimp.2009.01.010 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2009 Apr;9(4):455-62. doi: 10.1016/j.intimp.2009.01.010. 
      Epub 2009 Feb 2.