PMID- 19190248
OWN - NLM
STAT- MEDLINE
DCOM- 20090507
LR  - 20220408
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 113
IP  - 15
DP  - 2009 Apr 9
TI  - Adverse events among 2408 unrelated donors of peripheral blood stem cells: 
      results of a prospective trial from the National Marrow Donor Program.
PG  - 3604-11
LID - 10.1182/blood-2008-08-175323 [doi]
AB  - Limited data are available describing donor adverse events (AEs) associated with 
      filgrastim mobilized peripheral blood stem cell (PBSC) collections in unrelated 
      volunteers. We report results in 2408 unrelated PBSC donors prospectively 
      evaluated by the National Marrow Donor Program (NMDP) between 1999 and 2004. 
      Female donors had higher rates of AEs, requiring central line placement more 
      often (17% vs 4%, P< .001), experiencing more apheresis-related AEs (20% vs 7%, 
      P< .001), more bone pain (odds ratio [OR]=1.49), and higher rates of grades II-IV 
      and III-IV CALGB AEs (OR=2.22 and 2.32). Obese donors experienced more bone pain 
      (obese vs normal, OR=1.73) and heavy donors had higher rates of CALGB toxicities 
      (>95 kg vs <70 kg, OR=1.49). Six percent of donors experienced grade III-IV CALGB 
      toxicities and 0.6% experienced toxicities that were considered serious and 
      unexpected. Complete recovery is universal, however, and no late AEs attributable 
      to donation have been identified. In conclusion, PBSC collection in unrelated 
      donors is generally safe, but nearly all donors will experience bone pain, 1 in 4 
      will have significant headache, nausea, or citrate toxicity, and a small 
      percentage will experience serious short-term adverse events. In addition, women 
      and larger donors are at higher risk for donation-related AEs.
FAU - Pulsipher, Michael A
AU  - Pulsipher MA
AD  - University of Utah School of Medicine, Primary Children's Hospital, Salt Lake 
      City, UT 84132-2408, USA. michael.pulsipher@hsc.utah.edu
FAU - Chitphakdithai, Pintip
AU  - Chitphakdithai P
FAU - Miller, John P
AU  - Miller JP
FAU - Logan, Brent R
AU  - Logan BR
FAU - King, Roberta J
AU  - King RJ
FAU - Rizzo, J Douglas
AU  - Rizzo JD
FAU - Leitman, Susan F
AU  - Leitman SF
FAU - Anderlini, Paolo
AU  - Anderlini P
FAU - Haagenson, Michael D
AU  - Haagenson MD
FAU - Kurian, Seira
AU  - Kurian S
FAU - Klein, John P
AU  - Klein JP
FAU - Horowitz, Mary M
AU  - Horowitz MM
FAU - Confer, Dennis L
AU  - Confer DL
LA  - eng
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U24-CA76518/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20090203
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Recombinant Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - PVI5M0M1GW (Filgrastim)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Blood Cell Count
MH  - Blood Component Removal/*adverse effects/statistics & numerical data
MH  - *Blood Donors
MH  - Fatigue/epidemiology
MH  - Female
MH  - Filgrastim
MH  - Follow-Up Studies
MH  - Granulocyte Colony-Stimulating Factor/*adverse effects
MH  - Hematopoietic Stem Cell Mobilization/*adverse effects/statistics & numerical data
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology
MH  - Pain/*epidemiology
MH  - Prospective Studies
MH  - Recombinant Proteins
MH  - Risk Factors
MH  - Sex Distribution
MH  - Young Adult
PMC - PMC2668845
EDAT- 2009/02/05 09:00
MHDA- 2009/05/08 09:00
PMCR- 2009/04/09
CRDT- 2009/02/05 09:00
PHST- 2009/02/05 09:00 [entrez]
PHST- 2009/02/05 09:00 [pubmed]
PHST- 2009/05/08 09:00 [medline]
PHST- 2009/04/09 00:00 [pmc-release]
AID - S0006-4971(20)39361-7 [pii]
AID - 2008/175323 [pii]
AID - 10.1182/blood-2008-08-175323 [doi]
PST - ppublish
SO  - Blood. 2009 Apr 9;113(15):3604-11. doi: 10.1182/blood-2008-08-175323. Epub 2009 
      Feb 3.