PMID- 19190539 OWN - NLM STAT- MEDLINE DCOM- 20090924 LR - 20220310 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 65 IP - 5 DP - 2009 May TI - Brain-derived neurotrophic factor in infants <32 weeks gestational age: correlation with antenatal factors and postnatal outcomes. PG - 548-52 LID - 10.1203/PDR.0b013e31819d9ea5 [doi] AB - Neurotrophins (NTs) play important roles in brain growth and development. Cord blood (CB) brain-derived neurotrophic factor (BDNF) concentrations increase with gestational age but data regarding postnatal changes are limited. We measured BDNF concentrations after birth in 33 preterm infants <32-wk gestation. Serum was collected at birth (CB), at day 2, between day 6 and 10 (D6), at day 30 (D30), and at day 60 (D60). BDNF concentrations fell on D2 (p = 0.03), recovered by D6 (p = 0.10), and continued to rise thereafter at D30 (p = 0.06) and D60 (p = 0.01) compared with CB. CB BDNF concentrations positively correlated with duration of rupture of membranes (r = 0.43, p = 0.04). Antenatal steroids (ANS, p = 0.02), postnatal steroids (PNS, p = 0.04), and retinopathy of prematurity (ROP, p = 0.02) were identified as significant factors in multivariate analyses. The median (25-75th interquartile range) CB BDNF concentrations were higher in infants who received a complete course ANS compared with those who received a partial course [1461 (553-2064) versus 281 (171-536) pg/mL, p = 0.04]. BDNF concentrations negatively correlated with the use of PNS at D30 (r = -0.53, p = 0.002) and at D60 (r = -0.55, p = 0.009). PNS use was associated with reduced concentrations of BDNF at D30 [733 (101-1983) versus 2224 (1677- 4400) pg/mL, p = 0.004] and at D60 [1149 (288-2270) versus 2560 (1337-5166) pg/mL, p = 0.01]. BDNF concentrations on D60 in infants who developed ROP (n = 16) were lower than those who did not develop ROP (n = 7) [1417 (553-2540) versus 3593 (2620-7433) pg/mL, respectively, p = 0.005]. Our data suggests that BDNF concentrations rise beyond the first week of age. BDNF concentrations correlate with factors that influence neurodevelopment outcomes. FAU - Rao, Rakesh AU - Rao R AD - Department of Pediatrics, Washington University of St. Louis, St. Louis, Missouri 63110, USA. Rao_R@kids.wustl.edu FAU - Mashburn, Charles B AU - Mashburn CB FAU - Mao, Jingnan AU - Mao J FAU - Wadhwa, Nitin AU - Wadhwa N FAU - Smith, George M AU - Smith GM FAU - Desai, Nirmala S AU - Desai NS LA - eng GR - R01 NS040592/NS/NINDS NIH HHS/United States GR - R01 NS040592-09/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Steroids) SB - IM MH - Age Factors MH - Birth Weight MH - Brain/drug effects/growth & development/*metabolism MH - Brain-Derived Neurotrophic Factor/*blood MH - Bronchopulmonary Dysplasia/blood MH - Cerebral Hemorrhage/blood MH - *Child Development MH - Drug Administration Schedule MH - Enterocolitis, Necrotizing/blood MH - Female MH - Fetal Blood/*metabolism MH - Fetal Membranes, Premature Rupture/blood MH - Gestational Age MH - Humans MH - Infant, Newborn MH - *Infant, Premature MH - Male MH - Multivariate Analysis MH - Pregnancy MH - Prospective Studies MH - Retinopathy of Prematurity/blood MH - Steroids/administration & dosage PMC - PMC2735819 MID - NIHMS109425 EDAT- 2009/02/05 09:00 MHDA- 2009/09/25 06:00 PMCR- 2010/05/01 CRDT- 2009/02/05 09:00 PHST- 2009/02/05 09:00 [entrez] PHST- 2009/02/05 09:00 [pubmed] PHST- 2009/09/25 06:00 [medline] PHST- 2010/05/01 00:00 [pmc-release] AID - 10.1203/PDR.0b013e31819d9ea5 [doi] PST - ppublish SO - Pediatr Res. 2009 May;65(5):548-52. doi: 10.1203/PDR.0b013e31819d9ea5.