PMID- 19190544
OWN - NLM
STAT- MEDLINE
DCOM- 20090924
LR  - 20211203
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 65
IP  - 5
DP  - 2009 May
TI  - Long-term reduction of hippocampal brain-derived neurotrophic factor activity 
      after fetal-neonatal iron deficiency in adult rats.
PG  - 493-8
LID - 10.1203/PDR.0b013e31819d90a1 [doi]
AB  - Fetal-neonatal iron deficiency acutely alters hippocampal biochemistry, neural 
      morphology, and electrophysiology accompanied by a downregulation of 
      brain-derived neurotrophic factor (BDNF). These changes provide a cellular and 
      molecular basis for observed short-term learning and memory impairments. However, 
      the etiology of residual, long-term hippocampal neurotransmission abnormalities 
      and learning impairments after treatment remain unclear. Because BDNF modulates 
      learning and memory, we assessed its expression in 65-d-old formerly iron 
      deficient (FID) male rats that had been iron deficient during the fetal-neonatal 
      period and treated with iron since postnatal day 7. BDNF-III and -IV mRNAs and 
      BDNF protein expression remained down-regulated in FID rats when compared with 
      the always iron-sufficient rats. Expressions of BDNF activity-dependent 
      downstream targets (3-hydroxy-3-methylglutaryl CoA reductase and immediate early 
      genes c-fos, early growth response gene 1 and 2) were reduced in FID rats. In 
      turn, hippocampal expressions of direct targets of early-growth response genes, 
      including hypoxia-inducible factor 1, dual-specificity phosphatase 4, IGF 2, and 
      myelin basic protein were also diminished in FID rats. Collectively, 
      fetal-neonatal iron deficiency lowers hippocampal BDNF expression and function 
      beyond the period of iron deficiency. These findings may underlie the persistence 
      of learning deficits seen after fetal-neonatal iron deficiency.
FAU - Tran, Phu V
AU  - Tran PV
AD  - Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, 
      USA.
FAU - Fretham, Stephanie J B
AU  - Fretham SJ
FAU - Carlson, Erik S
AU  - Carlson ES
FAU - Georgieff, Michael K
AU  - Georgieff MK
LA  - eng
GR  - R01 HD29421/HD/NICHD NIH HHS/United States
GR  - F31 NS047876/NS/NINDS NIH HHS/United States
GR  - T32 MH073129-05/MH/NIMH NIH HHS/United States
GR  - R01 HD029421-14/HD/NICHD NIH HHS/United States
GR  - T32 MH073129/MH/NIMH NIH HHS/United States
GR  - T32MH073129/MH/NIMH NIH HHS/United States
GR  - R01 HD029421/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Early Growth Response Protein 2)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Egr2 protein, rat)
RN  - 0 (Hif1a protein, rat)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Iron, Dietary)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.1.3.16 (Mitogen-Activated Protein Kinase Phosphatases)
RN  - EC 3.1.3.48 (Dual-Specificity Phosphatases)
RN  - EC 3.1.3.48 (Dusp4 protein, rat)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Dual-Specificity Phosphatases/metabolism
MH  - Early Growth Response Protein 1/metabolism
MH  - Early Growth Response Protein 2/metabolism
MH  - Female
MH  - Gestational Age
MH  - Hippocampus/*metabolism
MH  - Hydroxymethylglutaryl CoA Reductases/metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Insulin-Like Growth Factor II/metabolism
MH  - *Iron Deficiencies
MH  - Iron, Dietary/administration & dosage
MH  - Male
MH  - Mitogen-Activated Protein Kinase Phosphatases/metabolism
MH  - Myelin Basic Protein/metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
PMC - PMC2715440
MID - NIHMS110299
EDAT- 2009/02/05 09:00
MHDA- 2009/09/25 06:00
PMCR- 2009/07/24
CRDT- 2009/02/05 09:00
PHST- 2009/02/05 09:00 [entrez]
PHST- 2009/02/05 09:00 [pubmed]
PHST- 2009/09/25 06:00 [medline]
PHST- 2009/07/24 00:00 [pmc-release]
AID - 10.1203/PDR.0b013e31819d90a1 [doi]
PST - ppublish
SO  - Pediatr Res. 2009 May;65(5):493-8. doi: 10.1203/PDR.0b013e31819d90a1.