PMID- 19190966
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20090309
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 16
IP  - 4
DP  - 2009 Apr
TI  - Lung cancer as a second primary malignancy: increasing prevalence and its 
      influence on survival.
PG  - 1033-8
LID - 10.1245/s10434-008-0296-1 [doi]
AB  - BACKGROUND: The purpose of this study was to review the experience with lung 
      cancer as a second primary malignancy (LCSPM) and to determine whether a history 
      of previous malignancy was an independent prognostic factor in resected non small 
      cell lung cancer (NSCLC). METHODS: We included 414 patients undergoing pulmonary 
      resection with a curative intention between January 1986 and January 2007. The 
      criteria for classifying a lesion as a lung cancer as a second primary malignancy 
      (LCSPM) were a different histological type or a tumor of identical histological 
      type occurring more than 3 years after treatment of the primary tumor, or 
      separated from the initial primary tumor by more than 2 cm of clinically normal 
      epithelium. RESULTS: Thirty-four patients (8.2%) had a history of a previous 
      malignancy. LCSPM were more frequent during the last decade (11.4% vs. 3.91%, P = 
      .0009). Breast, uroepithelial, and lung cancer were the most prevalent initial 
      primary tumors. In 64.7% of patients the time interval between the last 
      malignancy and the current lung cancer was 2 years or shorter. Patients with 
      NSCLC and a previous malignancy did not have a significantly different survival 
      rate than patients with the current NSCLC as the first malignancy (5-year 
      survival 65.3% vs. 58.6%, log-rank P = .416). CONCLUSION: The effectiveness of 
      the surgical resection and the subsequent survival of these patients appear to be 
      well demonstrated, and operative mortality and complications are no higher than 
      for other lung cancer patients.
FAU - Quadrelli, Silvia
AU  - Quadrelli S
AD  - Thoracic Oncology Center, British Hospital, Buenos Aires, Argentina. 
      silvia.quadrelli@gmail.com
FAU - Lyons, Gustavo
AU  - Lyons G
FAU - Colt, Henri
AU  - Colt H
FAU - Chimondeguy, Domingo
AU  - Chimondeguy D
FAU - Silva, Carlos
AU  - Silva C
LA  - eng
PT  - Journal Article
DEP - 20090204
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*epidemiology/surgery
MH  - Humans
MH  - Lung Neoplasms/*epidemiology/surgery
MH  - Neoplasms, Second Primary/*epidemiology/surgery
MH  - Prevalence
MH  - Prognosis
EDAT- 2009/02/05 09:00
MHDA- 2009/06/17 09:00
CRDT- 2009/02/05 09:00
PHST- 2008/08/08 00:00 [received]
PHST- 2008/12/02 00:00 [accepted]
PHST- 2008/12/02 00:00 [revised]
PHST- 2009/02/05 09:00 [entrez]
PHST- 2009/02/05 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
AID - 10.1245/s10434-008-0296-1 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2009 Apr;16(4):1033-8. doi: 10.1245/s10434-008-0296-1. Epub 2009 
      Feb 4.