PMID- 19192077 OWN - NLM STAT- MEDLINE DCOM- 20090707 LR - 20211020 IS - 1467-6494 (Electronic) IS - 0022-3506 (Print) IS - 0022-3506 (Linking) VI - 77 IP - 2 DP - 2009 Apr TI - Links between anxiety and allergies: psychobiological reality or possible methodological bias? PG - 347-62 LID - 10.1111/j.1467-6494.2008.00550.x [doi] AB - The objective of the study was to examine the link between anxiety and allergies to establish whether it reflects a psychobiological reality or a possible methodological bias. A cohort of 1,037 children enrolled in the study. Anxiety disorders were assessed between 11 and 21 years. Anxious personality was assessed at 18 years. Allergies were examined at 21 years by (a) self reports, (b) skin pricks, and (c) serum total immunoglobulin E (IgE). Self-reported allergies were predicted by recurrent anxiety disorders (OR [95% CI]=1.56 [1.06-2.30], p=.023) and self-reports of anxious personality (OR [95% CI]=1.67 [1.17-2.37], p=.004): Objectively verified allergies were not. These results suggest that the link between anxiety and allergies may reflect a methodological artifact rather than a psychobiological reality. FAU - Gregory, Alice M AU - Gregory AM AD - Psychology Department, Goldsmiths College, University of London, Lewisham Way, New Cross, London, SE14 6NW. a.gregory@gold.ac.uk FAU - Caspi, Avshalom AU - Caspi A FAU - Moffitt, Terrie E AU - Moffitt TE FAU - Milne, Barry J AU - Milne BJ FAU - Poulton, Richie AU - Poulton R FAU - Sears, Malcolm R AU - Sears MR LA - eng GR - MH45070/MH/NIMH NIH HHS/United States GR - R01 MH049414/MH/NIMH NIH HHS/United States GR - G0601483/MRC_/Medical Research Council/United Kingdom GR - MH49414/MH/NIMH NIH HHS/United States GR - G0100527/MRC_/Medical Research Council/United Kingdom GR - R01 MH045070/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20090202 PL - United States TA - J Pers JT - Journal of personality JID - 2985194R RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adolescent MH - Anxiety/diagnosis/epidemiology MH - Anxiety Disorders/*diagnosis/*epidemiology MH - Asthma/blood/*diagnosis/*epidemiology MH - Child MH - Comorbidity MH - Confidence Intervals MH - Disease Progression MH - Female MH - Humans MH - Immunoglobulin E/blood MH - Male MH - Odds Ratio MH - Skin Tests MH - United Kingdom/epidemiology MH - Young Adult PMC - PMC3752790 MID - NIHMS498888 EDAT- 2009/02/05 09:00 MHDA- 2009/07/08 09:00 PMCR- 2013/08/26 CRDT- 2009/02/05 09:00 PHST- 2009/02/05 09:00 [entrez] PHST- 2009/02/05 09:00 [pubmed] PHST- 2009/07/08 09:00 [medline] PHST- 2013/08/26 00:00 [pmc-release] AID - JOPY550 [pii] AID - 10.1111/j.1467-6494.2008.00550.x [doi] PST - ppublish SO - J Pers. 2009 Apr;77(2):347-62. doi: 10.1111/j.1467-6494.2008.00550.x. Epub 2009 Feb 2.